کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3209729 | 1587605 | 2009 | 8 صفحه PDF | دانلود رایگان |
BackgroundAcne inversa is a chronic inflammatory disorder of apocrine gland-bearing skin. The role of the innate immune system in the pathogenesis of the disease is controversial.ObjectivesWe investigated the expression of antimicrobial peptide/proteins in acne inversa.MethodsTissue samples were obtained from patients with acne inversa and compared with normal-appearing skin. The expression of psoriasin and human β-defensin (hBD)-2 on messenger RNA and protein level was analyzed.ResultsBoth messenger RNA and protein levels of psoriasin and hBD-2 were significantly increased in acne inversa. Macrophages expressing hBD-2 were found in the dermis.LimitationsSmall sample size is a limitation.ConclusionsAntimicrobial peptide/proteins are overexpressed in acne inversa lesions as compared with normal-appearing skin. The site of the major expression depends on the particular antimicrobial peptide/protein. Psoriasin is overexpressed in epidermal keratinocytes whereas hBD-2 is produced mainly by dermal macrophages, leaving a relative deficiency of hBD-2 in the epidermis of acne inversa lesions.
Journal: Journal of the American Academy of Dermatology - Volume 61, Issue 1, July 2009, Pages 58–65