کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3392517 | 1221224 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alloantigen-specific prolongation of allograft survival in recipient mice treated by alloantigen immunization following ultraviolet-B irradiation
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کلمات کلیدی
IFN-γPBSmAbsupernatantsTr1FCSIL-10MLRTregAPCCHSDTHMonoclonal antibody - آنتی بادی مونوکلونالantigen-presenting cells - آنتیژن ارائه سلولUltraviolet - اشعه فرابنفشstandard deviation - انحراف معیارinterferon-gamma - اینترفرون گاماinterleukin - اینترلوکینdelayed-type hypersensitivity - تاخیر نوع حساسیت بالاELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاTolerance - تلرانس Contact hypersensitivity - تماس با افزایش حساسیتGraft survival - زنده ماندنfetal calf serum - سرم گوساله جنینRegulatory T cells - سلولهای تی تنظیمکنندهSup - سوپPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریnot significant - مهم نیستTransplantation - پیوند
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alloantigen-specific prolongation of allograft survival in recipient mice treated by alloantigen immunization following ultraviolet-B irradiation Alloantigen-specific prolongation of allograft survival in recipient mice treated by alloantigen immunization following ultraviolet-B irradiation](/preview/png/3392517.png)
چکیده انگلیسی
It is well documented that ultraviolet (UV) radiation present in sunlight suppresses immune responses. However, the majority of studies documenting the immunosuppressive effects of UV irradiation have been carried out in animals exposed to UV irradiation before immunization. Here, we report that recipient mice exposed to UV irradiation 7Â days after immunization with a donor alloantigen exhibited prolongation of allograft survival in an alloantigen-specific manner. Recipient mice (H-2b) intravenously immunized with 2Â ÃÂ 107 allogeneic spleen cells (H-2b/d) 7Â days before UV irradiation (40Â kJ/m2) showed prolonged survival of allografts presenting the alloantigen used for sensitization (H-2b/d), but not third-party allografts (H-2b/k). Adoptive transfer experiments revealed that CD4+ T cells in UV-irradiated recipients were responsible for this prolongation. CD4+ T cells that could transfer the suppression produced large amounts of interleukin (IL)-10, but not IL-4. The effect of UV irradiation on alloantigen-specific immunosuppression was cancelled by administration of an anti-IL-10 monoclonal antibody. These results indicate that UV irradiation given after alloantigen immunization induces alloantigen-specific type 1 regulatory T cell-like regulatory T cells that prolong allograft survival and imply that the difficulties associated with predicting donor-related organ availability in transplantation can be dealt with, given the effectiveness of UV irradiation after immunization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 19, Issue 1, April 2008, Pages 45-54
Journal: Transplant Immunology - Volume 19, Issue 1, April 2008, Pages 45-54
نویسندگان
Tomohide Hori, Kagemasa Kuribayashi, Shinji Uemoto, Kanako Saito, Linan Wang, Mie Torii, Shintaro Shibutani, Kentaro Taniguchi, Shintaro Yagi, Taku Iida, Chiduru Yamamoto, Takuma Kato,