کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4179633 1276559 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic Studies of Psychosis: Current Findings, Methodological Approaches, and Implications for Postmortem Research
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Epigenetic Studies of Psychosis: Current Findings, Methodological Approaches, and Implications for Postmortem Research
چکیده انگلیسی

It has been widely speculated that epigenetic changes may play a role in the etiology of psychotic illnesses such as schizophrenia and bipolar disorder. Epigenetics is the study of mitotically heritable, but reversible, changes in gene expression that occur without a change in the genomic DNA sequence, brought about principally through alterations in DNA methylation and chromatin structure. Although numerous studies have examined psychosis-associated gene expression changes in postmortem brain samples, epigenetic studies of psychosis are in their infancy. In this article, we discuss methodologic and logistic issues related to epigenomic studies using postmortem brain tissue, before discussing the future implications of such research for our understanding of psychosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 69, Issue 2, 15 January 2011, Pages 146–156
نویسندگان
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