کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4180111 | 1276587 | 2008 | 6 صفحه PDF | دانلود رایگان |
BackgroundAbnormalities in the amygdala and hippocampus have been implicated in the pathogenesis of major depressive disorder (MDD). To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD).MethodsThirty-two psychotropic-naive patients with familial MDD, aged 8–21 years (12 males and 20 females), and 35 group-matched healthy participants (13 males and 22 females) underwent volumetric magnetic resonance imaging in order to evaluate hippocampal and amygdala volumes.ResultsPatients with familial MDD had significantly smaller left hippocampal (p = .007, effect size [d] = .44) and right hippocampal volumes (p = .025, d = .33) than controls. No differences were noted in amygdala volumes between groups (right: p > .05, left: p > .05). No correlations between hippocampal or amygdala volumes and demographic or clinical variables were noted.ConclusionsReduced hippocampal volume may be suggestive of a risk factor for developing MDD.
Journal: Biological Psychiatry - Volume 63, Issue 4, 15 February 2008, Pages 385–390