کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501184 | 1534626 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cognitive decline in type 2 diabetic db/db mice may be associated with brain region-specific metabolic disorders
ترجمه فارسی عنوان
کاهش شناختی در موش های دیابتی نوع 2 دیابتی / دیابتی ممکن است با اختلالات متابولیک خاص منطقه مغز مرتبط باشد
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کلمات کلیدی
InosineN-acetylaspartateADPT2DALAIMPGLNiNOASPNaASUCFWTLACAMPadenosine diphosphate - آدنوزین دی فسفاتadenosine monophosphate - آدنوزین مونوفسفرهaspartate - آسپارتاتalanine - آلانینγ-aminobutyric acid - اسید γ-آمینوبوتیریکCho - برایDiabetes - بیماری قندTaurine - تائورینTau - خود راType 2 diabetes - دیابت نوع 2Succinate - سوکینتینCognition - شناختmyo - فیبروئیدLactate - لاکتاتMetabolomics - متابولومیکMixed model - مدل مخلوطBrain - مغزRegion-specific - منطقه ویژهInosine monophosphate - مونوفسفات inosineMyo-inositol - میو-آنزیتولwild-type - نوع وحشی Nicotinamide adenine dinucleotide - نیکوتین آمید آدنین دینوکلئوتیدCholine - کولینGABA - گاباGlu - گلوglutamate - گلوتاماتglutamine - گلوتامینGly - گلیGlycine - گلیسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Type 2 diabetes has been associated with cognitive decline, but its metabolic mechanism remains unclear. In the present study, we attempted to investigate brain region-specific metabolic changes in db/db mice with cognitive decline and explore the potential metabolic mechanism linking type 2 diabetes and cognitive decline. We analyzed the metabolic changes in seven brain regions of two types of mice (wild-type mice and db/db mice with cognitive decline) using a 1H NMR-based metabolomic approach. Then, a mixed-model analysis was used to evaluate the effects of mice type, brain region, and their interaction on metabolic changes. Compared with the wild-type mice, the db/db mice with cognitive decline had significant increases in lactate, glutamine (Gln) and taurine as well as significant decreases in alanine, aspartate, choline, succinate, γ-Aminobutyric acid (GABA), glutamate (Glu), glycine, N-acetylaspartate, inosine monophosphate, adenosine monophosphate, adenosine diphosphate, and nicotinamide adenine dinucleotide. Brain region-specific metabolic differences were also observed between these two mouse types. In addition, we found significant interaction effects of mice type and brain region on creatine/phosphocreatine, lactate, aspartate, GABA, N-acetylaspartate and taurine. Based on metabolic pathway analysis, the present study suggests that cognitive decline in db/db mice might be linked to a series of brain region-specific metabolic changes, involving an increase in anaerobic glycolysis, a decrease in tricarboxylic acid (TCA) and Gln-Glu/GABA cycles as well as a disturbance in lactate-alanine shuttle and membrane metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1863, Issue 1, January 2017, Pages 266-273
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1863, Issue 1, January 2017, Pages 266-273
نویسندگان
Hong Zheng, Yongquan Zheng, Liangcai Zhao, Minjiang Chen, Guanghui Bai, Yongsheng Hu, Wenyi Hu, Zhihan Yan, Hongchang Gao,