کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5559341 | 1561565 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
28-Homocastasterone down regulates blood glucose, cholesterol, triglycerides, SREBP1c and activates LxR expression in normal & diabetic male rat
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کلمات کلیدی
ACCSREBP1c28-homocastasteronePEPCKLXRABCTATP-binding cassette transporters - ATP گیرنده های کاسه اتصالacetyl coA carboxylase - استیل کولا کربوکسیلازtriglyceride - تریگلیسریدtumor necrosis factor-α - تومور نکروز عامل αTNF-α - فاکتور نکروز توموری آلفاSterol regulatory element binding protein-1c - پروتئین متصل کننده پروتئین Sterlol-1cpyruvate carboxylase - پیرووات کربوکسیلازliver X receptor - کبد X گیرندهcholesterol - کلسترولBlood glucose - گلوکز خون یا قند خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Plant steroids are being recognized as influential secondary bio factors, assimilating in animal tissues through diet and affecting their cellular metabolic function to varying degree. They modulate catalytic and signaling functions in mammalian cells, affecting cellular homeostasis. The effect of phyto brassinosteroid ketoisoform 28-homocastasterone (28-HC), was assessed for its influence on blood glucose, plasma lipid and selective signal marker levels in normal and diabetic male wistar rat models. A 15 day oral feed regimen employing the experimental rat, noted that circulating blood glucose, cholesterol and triglyceride level in diabetic rat were markedly reduced by this compound. This study confirmed that the keto form had anti-hyperglycemic and anti-lipidemic potency associated with it and was available to man and animals in their diet. Western blots of marker protein, PCR amplicons of marker mRNA expressions and In Silico studies suggested that 28-HCeffect is being mediated through LxR molecular operatives in the rat cell.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 277, 1 November 2017, Pages 8-20
Journal: Chemico-Biological Interactions - Volume 277, 1 November 2017, Pages 8-20
نویسندگان
Velan Athithan, Kotteazeth Srikumar,