کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5648053 | 1587489 | 2017 | 7 صفحه PDF | دانلود رایگان |
BackgroundAtopic dermatitis is associated with other allergic conditions, but variations in this “atopic march” are poorly understood.ObjectiveTo determine the impact of the age of atopic dermatitis onset on the risk for asthma and seasonal allergies.MethodsA cohort study was performed using the Pediatric Eczema Elective Registry, which is an observational cohort of subjects with pediatric onset atopic dermatitis.ResultsIn total, 3966 children were included, and 73% reported atopic dermatitis onset before age 2Â years. At baseline, subjects with atopic dermatitis onset at ages 3 to 7 or 8 to 17Â years had significantly lower rates of seasonal allergies and asthma than those with onset before age 2. During follow-up, the adjusted relative risks for incident seasonal allergies were 0.82 (95% confidence interval, 0.72-0.91) and 0.64 (95% CI confidence interval, 0.47-0.83) in the 3- to 7- and 8- to 17-years-old at onset groups compared with the age 2Â years or younger at onset group. The adjusted risk for incident asthma was not significantly different between the older onset groups and the earliest onset group.LimitationsMisclassification bias may arise from using self-reported onset age data.ConclusionsThe timing of atopic dermatitis onset may explain part of the variation in the atopic march. These findings may improve future risk stratification of patients for treatment.
Journal: Journal of the American Academy of Dermatology - Volume 77, Issue 4, October 2017, Pages 634-640