کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5648588 | 1587504 | 2016 | 9 صفحه PDF | دانلود رایگان |
BackgroundThe current knowledge about potential risk factors for lymph node (LN) metastasis in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) is primarily based on studies that lack adjustment for confounding variables.ObjectivesWe sought to identify independent risk factors for LN metastasis in patients with HNcSCC and to evaluate the impact of LN metastasis on prognosis.MethodsPatients with primary HNcSCC were retrospectively included. Potential risk factors were analyzed by univariate and multivariate Cox regression models. Survival was compared using the Kaplan-Meier method.ResultsThree hundred thirty-six patients with 545 primary HNcSCCs were included. The median follow-up period was 43Â months (range, 1-176Â months). LN metastasis occurred in 55 patients (16.4%). The following independent risk factors of HNcSCC for the development of LN metastasis were identified: location on the ear, tumor diameter >50Â mm, moderate and poor differentiation, and tumor thickness >2Â mm. There was a significant decline in disease-specific survival and overall survival in patients with LN metastasis compared to patients without LN metastasis.LimitationsThe retrospective study design.ConclusionLN metastases from HNcSCC are common with diminished survival rates. This study confirmed some well-known risk factors, but also found moderate differentiation as an independent risk factor for LN metastasis.
Journal: Journal of the American Academy of Dermatology - Volume 75, Issue 4, October 2016, Pages 722-730