کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737370 | 1614714 | 2017 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis
ترجمه فارسی عنوان
تغییرات خواص درونی و سیناپسی نورون های شاخهای پشتی شکمی در یک مدل ماوس کولیت
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کلمات کلیدی
high thresholdWDRCRDIPSPIBSIBDTNBSSDHvisceral inflammationEPSP - epspiLow threshold - آستانه کمcolorectal distension - اختلال کولورکتالTrinitrobenzenesulfonic acid - اسید TrinitrobenzenesulfonicEffect size - اندازه اثرafterhyperpolarization - بعد از پمپاژInflammatory bowel disease - بیماریهای التهابی رودهanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceIn vivo - درون تنی یا درونجانداریCNS - دستگاه عصبی مرکزیRIN - رینirritable bowel syndrome - سندروم روده تحریک پذیر، کولیت عصبیcentral nervous system - سیستم عصبی مرکزیsuperficial dorsal horn - شاخ پشتی سطحیUnclassified - طبقه بندی نشدهSpinal cord - طناب نخاعیwide dynamic range - طیف گسترده ای پویاAHP - فرایند تحلیل سلسلهمراتبیinput resistance - مقاومت ورودیodds ratio - نسبت شانس هاexcitatory post synaptic potential - پتانسیل سیناپسی پست هیجان انگیزaction potential - پتانسیل عمل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5Â days after the induction of mild colitis in adult male mice (i.e. during acute inflammation of the colon). Whole-cell recordings were made from lumbosacral (L6-S1) superficial dorsal horn neurons (SDH), in animals under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to identify SDH neurons with colonic inputs, while stimulation of the hind paw and tail was employed to assess convergent cutaneous input. Following inflammation, a significantly increased proportion of SDH neurons received both colonic and cutaneous inputs, compared to neurons in naïve animals. In addition, the nature and magnitude of responses to CRD and cutaneous stimulation differed in inflamed animals, as was spontaneous excitatory synaptic drive. Conversely, several measures of intrinsic excitability were altered in a manner that would decrease SDH network excitability following colitis. We propose that during inflammation, sensitization of colonic afferents results in increased signaling to the SDH. This is accompanied by plasticity in SDH neurons whereby their intrinsic properties are changed to compensate for altered afferent activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 362, 24 October 2017, Pages 152-167
Journal: Neuroscience - Volume 362, 24 October 2017, Pages 152-167
نویسندگان
Kristen E. Farrell, Simon Keely, Marjorie M. Walker, Alan M. Brichta, Brett A. Graham, Robert J. Callister,