کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5832436 | 1122597 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The comparison of antioxidative and hepatoprotective activities of Codonopsis pilosula polysaccharide (CP) and sulfated CP
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MDAALTSCPBCGABTSDPPHLPST-SOD2,2-diphenyl-1-picrylhydrazyl - 2،2-دی فینیل-1-پریکیل هیدرازیلGSH-Px - GSH-PXAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییFourier transform-infrared spectroscopy - تبدیل فوریه طیف سنجی مادون قرمزtumor necrosis factor-α - تومور نکروز عامل αtotal superoxide dismutase - سوپراکسید دیسموتاز کلFT-IR - طیف سنجی مادون قرمز تبدیل فوریهTNF-α - فاکتور نکروز توموری آلفاAntioxidative activity - فعالیت آنتی اکسیداتیوHepatoprotective activity - فعالیت محافظتی محافظتیlipopolysaccharide - لیپوپلی ساکاریدmalondialdehyde - مالون دی آلدهیدHematoxylin and Eosin - هماتوکسیلین و ائوزینvitamin C - ویتامین سیtotal protein - کل پروتئینPositive control - کنترل مثبتModel control - کنترل مدلnegative control - کنترل منفیglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Codonopsis pilosula polysaccharide (CP) was extracted, purified and modified by chlorosulfonic acid-pyridine method to obtain a sulfated CP (sCP). Their antioxidative activities in vitro were compared through the free radical-scavenging test. The results demonstrated that the scavenging capabilities of sCP were significantly stronger than those of CP. In vivo test, the mice hepatic injury model was prepared by BCG/LPS method, then administrated respectively with sCP and CP at three dosages, the biochemical indexes in serum, antioxidative indexes in liver homogenate and histopathological change in liver of the mice were compared. The results showed that in high (200 mg/kg) and middle (150 mg/kg) dosages of sCP groups, the contents of ALT, AST and TNF-α in serum and MDA in liver homogenate were significantly lower than those in the model group and numerically lower than those in the CP groups, the activities of SOD and GSH-Px in liver homogenate were significantly higher than those in the model group and numerically higher than those in the CP groups. In the model group there were obvious pathological changes in the liver, while in the sCP groups were near normal. These results indicate that sCP and CP possess antioxidative activity in vitro and in vivo, the activity of sCP is stronger than that of CP and sulfation modification can enhance the antioxidative and hepatoprotective activities of Codonopsis pilosula polysaccharide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 24, Issue 2, February 2015, Pages 299-305
Journal: International Immunopharmacology - Volume 24, Issue 2, February 2015, Pages 299-305
نویسندگان
Cui Liu, Jin Chen, Entao Li, Qiang Fan, Deyun Wang, Peng Li, Xiuping Li, Xingying Chen, Shulei Qiu, Zhenzhen Gao, Hongquan Li, Yuanliang Hu,