Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals

► Aging affects glutamatergic signaling in hippocampus. ► Mitochondrial calcium is related with this aged-alteration. ► There is a reduction in glutamate responses in hippocampus in aged rats. ► Sleep restriction induces increase in calcium signaling in hippocampus of aged rats. ► Apoptosis is elevated in aged animals and even more in sleep restricted rats.