کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5848166 | 1130139 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides
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کلمات کلیدی
ALBCREALTSIMCAPyrethroidDmgFIDsDDVPTSPNACTMAOLD50DMA1H NMR spectra - 1H NMR طیف1H NMR - 1H-NMRPCA - PCAfree induction decays - آزاد شدن القاء آزادAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازAlbumin - آلبومینALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییPrincipal components analysis - تجزیه و تحلیل اجزای اصلیTrimethylamine-n-oxide - تریمتییلامین-n-اکسیدBUN - خوبDeltamethrin - دلتامترینdimethylglycine - دی متیل گلیسینDimethylamine - دی متیلامینDichlorvos - دیوکلروفوز1H nuclear magnetic resonance - رزونانس مغناطیسی هسته ای -1Organophosphorus pesticide - سموم دفع آفات فسفرCombined toxicity - سمیت ترکیب شدهMIx - مخلوط کردنSoft independent modeling of class analogy - مدل سازی مستقل نرمال از تقابل کلاسblood urea nitrogen - نیتروژن اوره خونcreatinine - کراتینینCHE - کهCholinesterase - کولین استراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Metabonomic analysis, clinical chemical analysis and histopathology were used to investigate the toxic effects of subchronic exposure to dichlorvos, deltamethrin, and a combination of these two pesticides, in rats. Weight loss, hind limb weakness and histopathological changes in kidney tissue were only observed in rats exposed to high doses of deltamethrin, or a combination of deltamethrin and dichlorvos. Urinary metabonomic analysis indicated that exposure to a mixture of dichlorvos and deltamethrin was followed by increases in urinary lactate, dimethylamine, N-glycoprotein (NAC) and glycine similar to those observed in rats treated with either dichlorvos or deltamethrin alone. Serum metabonomic analysis suggests that dichlorvos induced an increase in lactate and alanine and a decrease in dimethylglycine (DMG), NAC and very low- and low-density lipoprotein (VLDL/LDL). High levels of lactate and low levels of NAC and VLDL/LDL were observed in the deltamethrin treatment group. Treating rats with a mixture of dichlorvos and deltamethrin caused an increase in serum lactate, trimethylamine-N-oxide (TMAO), choline and alanine, with the highest levels of these metabolites observed in those that received the highest dose. Exposure to a mixture of dichlorvos and deltamethrin also resulted in a decrease in serum acetone, DMG, NAC, and VLDL/LDL. Changes in serum TMAO, alanine, choline and acetone in this treatment group were higher than in rats treated with either dichlorvos or deltamethrin. These results suggest that exposing rats to subchronic doses of dichlorvos, deltamethrin, or a combination of these pesticides, disrupted the energy metabolism of the liver and reduced kidney function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 203, Issue 3, 25 May 2013, Pages 588-596
Journal: Chemico-Biological Interactions - Volume 203, Issue 3, 25 May 2013, Pages 588-596
نویسندگان
Hui-Ping Wang, Yu-Jie Liang, Ying-Jian Sun, Jia-Xiang Chen, Wei-Yuan Hou, Ding-Xin Long, Yi-Jun Wu,