کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850846 | 1561781 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis
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کلمات کلیدی
rennin-angiotensin systemAngiotensin receptor 1MDACK-MBAT1CATDCMSTZΔΨmRASGSH-Px - GSH-PXROS - ROStaxifolin - taxfilinAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Angiotensin II - آنژیوتانسین دوstreptozotocin - استرپتوزوتوسینNADPH oxidase - اکسیداز NADPH Oxidative stress - تنش اکسیداتیوApoptosis - خزان یاختهایAng II - دومSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH malondialdehyde - مالون دی آلدهیدMitochondrial membrane potential - پتانسیل غشای میتوکندریCatalase - کاتالازdiabetic cardiomyopathy - کاردیومیوپاتی دیابتی یا بیماری قلبی دیابتیejection fraction - کسری خروجیfractional shortening - کوتاه کردن کسریglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis](/preview/png/5850846.png)
چکیده انگلیسی
Diabetic cardiomyopathy has been increasingly recognized as an important cause of heart failure in diabetic patients. Excessive oxidative stress has been suggested to play a critical role in the development of diabetic cardiomyopathy. The objective of this study was to investigate the potential protective effects and mechanisms of taxifolin on cardiac function of streptozotocin-induced diabetic mice and on hyperglycemia-induced apoptosis of H9c2 cardiac myoblasts. In vivo study revealed that taxifolin improved diastolic dysfunction, ameliorated myocardium structure abnormality, inhibited myocyte apoptosis and enhanced endogenous antioxidant enzymes activities. Interestingly, taxifolin reduced angiotensin II level in myocardium, inhibited NADPH oxidase activity, and increased JAK/STAT3 activation. In vitro investigation demonstrated that taxifolin inhibited 33Â mM glucoseinduced H9c2 cells apoptosis by decreasing intracellular ROS level. It also inhibited caspase-3 and caspase-9 activation, restored mitochondrial membrane potential, and regulated the expression of proteins related to the intrinsic pathway of apoptosis, thus inhibiting the release of cytochrome c from mitochondria into the cytoplasm. In conclusion, taxifolin exerted cardioprotective effects against diabetic cardiomyopathy by inhibiting oxidative stress and cardiac myocyte apoptosis and might be a potential agent in the treatment of diabetic cardiomyopathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 63, January 2014, Pages 221-232
Journal: Food and Chemical Toxicology - Volume 63, January 2014, Pages 221-232
نویسندگان
Xiao Sun, Rong-chang Chen, Zhi-hong Yang, Gui-bo Sun, Min Wang, Xiao-jun Ma, Li-juan Yang, Xiao-bo Sun,