کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5890480 | 1568161 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat
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کلمات کلیدی
Dried plumP1NPpTHBFRovariectomizedOVXIGF-IDPDDXATRAPOPGBMDAINBAPMARRANKLRUNX2NFATc1TbNTbThμCTTbSpBV/TV - BV / TVVOI - CANALP - آلکالن فسفاتازbone-specific alkaline phosphatase - آلکالن فسفاتاز ویژه استخوانAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییOsteoprotegerin - استئوپروتگرینBone histomorphometry - استخوان هیستومورفومتریEstrogen - استروژنSprague Dawley - اسپراگ داولیTartrate resistant acid phosphatase - اسید فسفاتاز مقاوم در برابر تتراتconnectivity density - تراکم اتصالBone mineral density - تراکم معدنی استخوانtumor necrosis factor-alpha - تومور نکروز عامل آلفاMicro-computed tomography - توموگرافی کامپیوتری میکروtrabecular separation - جداسازی ترابکولارdual-energy X-ray absorptiometry - جذب اندازه گیری اشعه ایکس دوگانه انرژیvolume of interest - حجم سودGastrointestinal tract - دستگاه گوارشmineralizing surface - سطح مینرالیزهSham - شامsham operated - شام کار کردtrabecular number - شماره تراککالtrabecular thickness - ضخامت تراککالInsulin-like growth factor-I - عامل رشد انسولین مانند IRunt-related transcription factor 2 - عامل رونویسی مرتبط با روت 2TNF-α - فاکتور نکروز توموری آلفاBMP - مدیریت فرایند کسب و کارAmerican Institute of Nutrition - موسسه تغذیه ای آمریکاbone formation rate - میزان تشکیل استخوانMineral apposition rate - میزان جذب مواد معدنیparathyroid hormone - هورمون پاراتیروئیدBone morphogenetic protein - پروتئین مورفوژنیک استخوانOsteoporosis - پوکی استخوانType I collagen - کلاژن نوع IMenopause - یائسگی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dried plum has been reported to have potent effects on bone in osteopenic animal models, but the mechanisms through which bone metabolism is altered in vivo remain unclear. To address this issue, a study comparing the metabolic response of dried plum to the anabolic agent, parathyroid hormone (PTH), was undertaken. Six month-old female Sprague Dawley rats (n = 84) were sham-operated (SHAM) or ovariectomized (OVX) and maintained on a control diet for 6 wks until osteopenia was confirmed. Treatments were initiated consisting of a control diet (AIN-93M) supplemented with dried plum (0, 5, 15 or 25%; w/w) or a positive control group receiving PTH. At the end of 6 wks of treatment, whole body and femoral bone mineral density (BMD) were restored by the two higher doses of dried plum to the level of the SHAM group. Trabecular bone volume and cortical thickness were also improved with these two doses of dried plum. Dried plum suppressed the OVX-induced increase in bone turnover as indicated by systemic biomarkers of bone metabolism, N-terminal procollagen type 1 (P1NP) and deoxypyridinoline (DPD). Dynamic bone histomorphometric analysis of the tibial metaphysis revealed that dried plum restored the OVX-induced increase in cancellous bone formation rate (BFR) and mineralizing surface (MS/BS) to the SHAM group, but some doses of dried plum increased endocortical mineral apposition rate (MAR). As expected, PTH significantly increased endocortical MAR and BFR, periosteal BFR, and trabecular MAR and BFR beyond that of the OVX and maintained the accelerated rate of bone resorption associated with OVX. Dried plum up-regulated bone morphogenetic protein 4 (Bmp4) and insulin-like growth factor 1 (Igf1) while down-regulating nuclear factor T cell activator 1 (Nfatc1). These findings demonstrate that in the adult osteopenic OVX animal, the effects of dried plum differ from that of PTH in that dried plum primarily suppressed bone turnover with the exception of the indices of bone formation at the endocortical surface.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 58, January 2014, Pages 151-159
Journal: Bone - Volume 58, January 2014, Pages 151-159
نویسندگان
Brenda J. Smith, So Young Bu, Yan Wang, Elizabeth Rendina, Yin F. Lim, Denver Marlow, Stephen L. Clarke, Diane M. Cullen, Edralin A. Lucas,