کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6064171 1201859 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reviews and feature articleRole of platelets in allergic airway inflammation
ترجمه فارسی عنوان
بررسی و ویژگی مقاله رول پلاکتها در التهاب آلرژیک هوایی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Increasing evidence suggests an important role for platelets and their products (eg, platelet factor 4, β-thromboglobulin, RANTES, thromboxane, or serotonin) in the pathogenesis of allergic diseases. A variety of changes in platelet function have been observed in patients with asthma, such as alterations in platelet secretion, expression of surface molecules, aggregation, and adhesion. Moreover, platelets have been found to actively contribute to most of the characteristic features of asthma, including bronchial hyperresponsiveness, bronchoconstriction, airway inflammation, and airway remodeling. This review brings together the current available data from both experimental and clinical studies that have investigated the role of platelets in allergic airway inflammation and asthma. It is anticipated that a better understanding of the role of platelets in the pathogenesis of asthma might lead to novel promising therapeutic approaches in the treatment of allergic airway diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 135, Issue 6, June 2015, Pages 1416-1423
نویسندگان
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