کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6064601 | 1201863 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Do lipids influence the allergic sensitization process?
ترجمه فارسی عنوان
آیا لیپید ها بر روند حساسیت آلرژیک تاثیر می گذارد؟
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کلمات کلیدی
TLRMoDCiNKTMD-2nsLTPFood allergens - آلرژن های غذاییPollen allergens - آلرژن های گردهAllergy - آلِرژیToll-like receptor - تیالآرDendritic cell - سلول دندریتیکmyeloid differentiation factor 2 - عامل تمایز میلوئید 2invariant natural killer T - غیر طبیعی قاتل TMicrobial lipids - لیپیدهای میکروبیPalm - نخلnonspecific lipid transfer protein - پروتئین انتقال ناسازات چربی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Allergic sensitization is a multifactorial process that is not only influenced by the allergen and its biological function per se but also by other small molecular compounds, such as lipids, that are directly bound as ligands by the allergen or are present in the allergen source. Several members of major allergen families bind lipid ligands through hydrophobic cavities or electrostatic or hydrophobic interactions. These allergens include certain seed storage proteins, Bet v 1-like and nonspecific lipid transfer proteins from pollens and fruits, certain inhalant allergens from house dust mites and cockroaches, and lipocalins. Lipids from the pollen coat and furry animals and the so-called pollen-associated lipid mediators are codelivered with the allergens and can modulate the immune responses of predisposed subjects by interacting with the innate immune system and invariant natural killer T cells. In addition, lipids originating from bacterial members of the pollen microbiome contribute to the outcome of the sensitization process. Dietary lipids act as adjuvants and might skew the immune response toward a TH2-dominated phenotype. In addition, the association with lipids protects food allergens from gastrointestinal degradation and facilitates their uptake by intestinal cells. These findings will have a major influence on how allergic sensitization will be viewed and studied in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 134, Issue 3, September 2014, Pages 521-529
Journal: Journal of Allergy and Clinical Immunology - Volume 134, Issue 3, September 2014, Pages 521-529
نویسندگان
Merima PhD, Thomas MD, Heimo PhD,