Inhibition of differentiation, amplification, and function of human TH17 cells by intravenous immunoglobulin

These results reveal a novel mechanism of action of IVIg in achieving a therapeutic effect in autoimmune and allergic diseases, in which TH17 cells play a key modulatory role in sustaining the chronic inflammatory response. Our results also suggest a reciprocal regulation of TH17 and regulatory T-cell populations by IVIg.