کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6068254 | 1587132 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks
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کلمات کلیدی
APINHLBIFeNOICSOCsAsthma - آسمAIMS - اهدافCare - اهمیت دادنPeak - اوجemergency department - بخش اورژانسChildhood Asthma Research and Education - تحقیقات و آموزش آسم دوران کودکیWheezing - خستگیAsthma Predictive Index - شاخص پیش بینی آسمMIST - غبارfractional concentration of exhaled nitric oxide - غلظت کسر اکسید نیتریک اکساید شدهNational Heart, Lung, and Blood Institute - قلب ملی، ریه و موسسه خونInfant - نوزادPreschool children - کودکان پیش دبستانیInhaled corticosteroids - کورتیکواستروئیدهای استنشاقیoral corticosteroids - کورتیکواستروئیدهای خوراکی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Recurrent wheezing in the preschool children is a common clinical problem, often associated with significant morbidity related to acute episodes. The management of these children has been complicated by a paucity of high-quality clinical trials in this age group. To fill this knowledge gap, National Heart, Lung, and Blood Institute's asthma research networks have performed a series of clinical trials in an effort to provide practitioners with guidance on appropriate management strategies. These studies establish daily inhaled corticosteroid (ICS) therapy in toddlers at high risk for subsequent asthma as an effective approach for the prevention of exacerbations and symptom reduction, but without evidence of disease-modifying properties. Additional studies have confirmed substantial heterogeneity in ICS response, in terms of both efficacy and effect on linear growth. Treatment with intermittent high-dose ICS was demonstrated to be an alternative approach to daily low-dose ICS for preventing severe exacerbations in toddlers with intermittent but significant wheeze and a positive modified asthma predictive index. This review details the findings and clinical implications derived from these studies, discuss the utility of biomarkers and the role of oral corticosteroids during acute exacerbations, and summarizes ongoing clinical trials in this age group.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Allergy and Clinical Immunology: In Practice - Volume 4, Issue 1, JanuaryâFebruary 2016, Pages 1-8
Journal: The Journal of Allergy and Clinical Immunology: In Practice - Volume 4, Issue 1, JanuaryâFebruary 2016, Pages 1-8
نویسندگان
Avraham MD, MSCI, Leonard B. MD,