کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6072762 1587530 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleA population-based study of the association between bullous pemphigoid and neurologic disorders
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Original articleA population-based study of the association between bullous pemphigoid and neurologic disorders
چکیده انگلیسی

BackgroundBullous pemphigoid (BP) has been associated with neurologic disorders.ObjectiveWe sought to analyze the association between BP and neurologic disorders.MethodsWe retrospectively identified residents of Olmsted County, Minnesota, with a first lifetime diagnosis of BP between January 1, 1960, and December 31, 2009. Three age- and sex-matched Olmsted County, Minnesota, residents without BP were selected as control subjects for each patient. We compared history of or development of neurologic disorders (dementia, Alzheimer disease, Parkinson disease, multiple sclerosis, cerebrovascular disease, and seizures) between groups using case-control and cohort designs.ResultsIn all, 87 patients with BP were identified and matched to 261 control subjects. The odds of a previous diagnosis of any neurologic disorder or a history of dementia were significantly increased among cases compared with controls (odds ratio 6.85; 95% confidence interval [CI] 3.00-15.64; P < .001; and odds ratio 6.75; 95% CI 2.08-21.92; P = .002, respectively). Both Parkinson disease (hazard ratio 8.56; 95% CI 1.55-47.25; P = .01) and any type of neurologic disorder (hazard ratio 2.02; 95% CI 1.17-3.49; P = .01) were significantly more likely to develop during follow-up in patients with than without BP.LimitationsSmall geographic area and retrospective study design are limitations.ConclusionFindings confirmed an association of BP with neurologic disorders, especially dementia and Parkinson disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Dermatology - Volume 71, Issue 6, December 2014, Pages 1191-1197
نویسندگان
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