کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074779 | 1203488 | 2016 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model
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کلمات کلیدی
TSLPLEKTITMGNHE1KLKFLGTh2SPFTEWLKallikreinPAR2NGFT-helper 2 - T helper 2Transepidermal water loss - از دست دادن آب دریچهLactobionic acid - اسید لاکتوبیکspecific pathogen-free - خاص بدون پاتوژنAtopic dermatitis - درماتیت آتوپیکnerve growth factor - فاکتور رشد عصبfilaggrin - فیلهگرینStratum corneum - لایه شاخی، استراتوم کورنئومLBA - لباThymic stromal lymphopoietin - لنفوپیتین استروما تیمیکprotease-activated receptor 2 - گیرنده فعال فعال پروتئاز 2
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model](/preview/png/6074779.png)
چکیده انگلیسی
Elevated skin surface pH has been reported in patients with atopic dermatitis. In this study, we explored the role of skin pH in the pathogenesis of atopic dermatitis using the NC/Tnd murine atopic dermatitis model. Alkalinization of the skin of asymptomatic NC/Tnd mice housed in specific pathogen-free conditions induced kallikrein 5 and activated protease-activated receptor 2, resulting in thymic stromal lymphopoietin secretion and a cutaneous T-helper 2 allergic response. This was associated with increased transepidermal water loss and development of eczematous lesions in these specific pathogen-free NC/Tnd mice, which normally do not suffer from atopic dermatitis. Injection of recombinant thymic stromal lymphopoietin also induced scratching behavior in the specific pathogen-free NC/Tnd mice. Thymic stromal lymphopoietin production and dermatitis induced by alkalinization of the skin could be blocked by the protease-activated receptor 2 antagonist ENMD-1068. In contrast, weak acidification of eczematous skin in conventionally housed NC/Tnd mice reduced kallikrein 5 activity and ameliorated the dermatitis. Onset of the dermatitis was associated with increased epidermal filaggrin expression and impaired activity of the sodium/hydrogen exchanger 1, a known regulator of skin pH. We conclude that alterations in skin pH directly modulate kallikrein 5 activity leading to skin barrier dysfunction, itch, and dermatitis via the protease-activated receptor 2-thymic stromal lymphopoietin pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 1, January 2016, Pages 127-135
Journal: Journal of Investigative Dermatology - Volume 136, Issue 1, January 2016, Pages 127-135
نویسندگان
Hyosun Jang, Akira Matsuda, Kyungsook Jung, Kaoru Karasawa, Kenshiro Matsuda, Kumiko Oida, Saori Ishizaka, Ginnae Ahn, Yosuke Amagai, Changjong Moon, Sung-Ho Kim, Peter D. Arkwright, Kenji Takamori, Hiroshi Matsuda, Akane Tanaka,