کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6314354 | 1619069 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
HCBTrans-nonachlordaneHRGCPIVUSTEQHRMSOCDDTCDDHWPPCBsTNCBDE2,3,7,8-Tetrachlorodibenzo-p-dioxin - 2،3،7،8-تترا کلریدیبنزوپتوفان دیوکسینDNA - DNA یا اسید دزوکسی ریبونوکلئیکp,p′-DDE - p، p'-DDEAryl hydrocarbon - آرویل هیدروکربنPersistent organic pollutants - آلایندههای آلی دیرپا(پایدار)Organochlorine - ارگانوکلرینdeoxyribonucleic acid - اسید deoxyribonucleicRNA - اسید ریبونوکلئیکribonucleic acid - اسید ریبونوکلئیکOctachlorodibenzo-p-dioxin - اکتاوکلودیبنزو-دی-دیوکسینProspective Investigation of the Vasculature in Uppsala Seniors - بررسی آیندهی عروق در روانپزشکان اوپسالاHexachlorobenzene - بنزن هگزاکلراید، هگزاکلروبنزنPolychlorinated biphenyls - بیفنیل پلیکلر World Health Organization - سازمان بهداشت جهانیElderly - سالمندیhigh-resolution mass spectrometry - طیف سنجی جرمی با وضوح بالاconfidence interval - فاصله اطمینانLuma - لوماDNA methylation - متیلاسیون DNAtoxic equivalency - معادل سمیpop - پاپSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population](/preview/png/6314354.png)
چکیده انگلیسی
Dioxin exposure has experimentally been associated with changes in DNA methylation, an epigenetic change that is associated with disease. The present study aims to investigate if serum levels of dioxin and other persistent environmental pollutants are related to global DNA methylation in a human sample. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (all aged 70), global DNA methylation was measured by the Luminometric Methylation Assay in 524 subjects. Twenty-three different POPs, including 16 PCBs, five pesticides, one dioxin (OCDD) and one brominated flame retardant (BDE47) were analysed by HRGC/HRMS. Ten single nucleotide polymorphisms (SNPs) in the Aryl hydrocarbon (Ah)-receptor were analysed by mini-sequencing. High levels of toxic equivalency (TEQ) for PCBs and dioxin were associated with DNA hypermethylation (p = 0.030). This was mainly attributed to coplanar non-ortho PCBs. While no significant associations were found between DNA methylation and SNPs in the Ah-receptor, an interaction was found between the SNP rs2237297 and TEQ so that TEQ was associated with hypermethylation (p = 0.009) only in subjects with one G-allele (n = 103). Also high levels of the PCB126 congener, the OCDD, and the pesticide metabolite p,pâ²-DDE were related to DNA hypermethylation (p = 0.01, 0.03 and 0.003, respectively). In conclusion, in a sample of elderly subjects, high TEQ including PCBs and the dioxin OCDD and high serum levels of PCB126, OCDD, and p,pâ²-DDE were related to global DNA hypermethylation in a cross-sectional analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 59, September 2013, Pages 456-461
Journal: Environment International - Volume 59, September 2013, Pages 456-461
نویسندگان
Lars Lind, Johanna Penell, Karin Luttropp, Louise Nordfors, Anne-Christine Syvänen, Tomas Axelsson, Samira Salihovic, Bert van Bavel, Tove Fall, Erik Ingelsson, P. Monica Lind,