Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds

► The use of in situ self assembling (pro-nano) lipospheres is a suitable strategy to enhance the oral bioavailability of lipophilic drugs. ► Lipospheres can be utilized for drug administration via oral, ocular and parenteral routes. ► Some lipospheres advantages are: high stability and dispersibility, controlled particle size, high drug entrapment and extended release. ► The review focuses on preparation, physicochemical properties, in vitro evaluation and biopharmaceutical properties of lipospheres and PNL.