Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

Chrysin (5,7-dihydroxyflavone), a natural polyphenol, occurs in many plants, honey, and propolis. It appears to have a blend of many pharmacological activities such as anticarcinogenic, pro-apoptotic, antiangiogenic, antimetastatic, immunomodulatory, and antioxidant properties. The molecular mechanisms underlying the pleotropic activities of chrysin are diverse, which involve combinations of cell signaling pathways at multiple levels of various diseases. Chrysin mitigates neurotoxicity, neuroinflammation, and oxidative stress.184