کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8302314 | 1537726 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency
ترجمه فارسی عنوان
تبدیل متابولیک اسیدهای چرب ضروری حاوی دتریم در داخل آمنیونی توسط موش های جنینی به دنبال کمبود اسید چرب امگا 3
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کلمات کلیدی
ALAethanolamine phosphoglycerideDeuteratedDocosatetraenoic acidSPGCpGDPADTAIPG - GPAArachidonic acid - اسید آراشیدونیکalpha-linolenic acid - اسید آلفا لینولنیکdocosapentaenoic acid - اسید داکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکLinoleic acid - اسید لینولئیکFatty acid - اسید چربPolyunsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعepg - اپگDHA - دوکوساهگزائنوئیک اسیدPhospholipids - فسفولیپیدamniotic fluid - مایع آمنیوتیکFetal metabolism - متابولیسم جنینیBrain - مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Accumulation of polyunsaturated fatty acids (PUFA) in the fetal brain is accomplished predominantly via a highly selective flow of docosahexaenoic acid (22:6n-3, DHA) and arachidonic acid (20:4n-6, AA) through the placenta. Little is known regarding the endogenous capability of the fetus to generate its own DHA and AA from lower homologues such as linolenic (18:3n-3, ALA) and linoleic (18:2n-6, LA) acids, respectively. Deuterium-labeled d5-ALA and d5-LA at millimolar concentrations were injected directly into the amniotic fluid in order to investigate maternal-independent metabolic conversion of the stable isotopes in brain and liver of the fetus near delivery. After 48 h under adequate maternal diet, the levels of d5-ALA metabolites in the fetal brain and fetal liver were 45 ± 2.2 pmol/mg and 86 ± 4 pmol/mg of which 79% and 63.6% were comprised of d5-DHA. At this time point, incorporation of d5-LA metabolites was 103 ± 5 pmol/mg and 772 ± 46 pmol/mg for brain and liver, of which 50% and 30% were comprised of d5-AA. Following sustained maternal dietary ALA deficiency, the levels of total d5-ALA derived metabolites in the fetal brain and fetal liver were increased to 231 pmol/mg and 696 pmol/mg of which 71% and 26% were comprised of d5-DHA. From the time course and relative rates of d5-ALA precursor displacement by d5-DHA in cellular phosphoglycerides, it is concluded that the fetal rat brain can generate its own DHA from its d5-ALA precursors particularly under dietary stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 9, September 2014, Pages 1336-1344
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 9, September 2014, Pages 1336-1344
نویسندگان
Ephraim Yavin, Yu Hong Lin, Annette Brand, Norman Jr.,