کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336346 | 1540611 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Beneficial psychological effects of novel psychobiotics in diabetic rats: the interaction among the gut, blood and amygdala
ترجمه فارسی عنوان
اثرات روانشناختی مفید روبینیویت های جدید در موش های دیابتی: تعامل بین روده، خون و آمیگدال
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کلمات کلیدی
TACMDAT2DMSTZFSTHFDEPMLPSGPXCATBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Forced swimming test - آزمون اجباری شناstreptozotocin - استرپتوزوتوسینelevated plus maze - بالا به همراه پیچ و خمOat - جو دو سرType 2 diabetes mellitus - دیابت نوع دوhigh-fat diet - رژیم غذایی با چربی بالاSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازTotal antioxidant capacity - ظرفیت آنتی اکسیدانی کلBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزLipopolysaccharides - لیپوپلی ساکارید هاmalondialdehyde - مالون دی آلدهیدInsulin resistance - مقاومت به انسولینHPA - میلی بار یا هکتوپاسکالhypothalamus–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Type 2 diabetes mellitus (T2DM) can lead to major complications such as psychiatric disorders which include depressive and anxiety-like behaviors. The association of the gut-brain axis in the development of such disorders, especially in T2DM, has been elucidated; however, gut dysbiosis is also reported in patients with T2DM. Hence, the regulation of the gut-brain axis, in particular, the gut-amygdala, as a vital region for the regulation of behavior is essential. Thirty-five male Wistar rats were divided into six groups. To induce T2DM, treatment groups received high-fat diet and 35 mg/kg streptozotocin. Then, supplements of Lactobacillus plantarum, inulin or their combination were administered to each group for 8 weeks. Finally, the rats were sacrificed for measurement of blood and tissue parameters after behavioral testing. The findings demonstrated the favorable effects of the psychobiotics (L. plantarum, inulin or their combination) on oxidative markers of the blood and amygdala (superoxide dismutase, glutathione peroxidase, malondialdehyde and total antioxidant capacity), as well as on concentrations of amygdala serotonin and brain-derived neurotrophic factor, in the diabetic rats. In addition, beneficial effects were observed on the elevated plus maze and forced swimming tests with no change in locomotor activity of the rats. There was a strong correlation between the blood and amygdala oxidative markers, insulin and fasting blood sugar with depressive and anxiety-like behaviors. Our results identified L. plantarum ATCC 8014 and inulin or their combination as novel psychobiotics that could improve the systemic and nervous antioxidant status and improve amygdala performance and beneficial psychotropic effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 57, July 2018, Pages 145-152
Journal: The Journal of Nutritional Biochemistry - Volume 57, July 2018, Pages 145-152
نویسندگان
Mohammad Morshedi, Khadijeh Bavafa Valenlia, Elaheh Sadat Hosseinifard, Parviz Shahabi, Mehran Mesgari Abbasi, Meysam Ghorbani, Abolfazl Barzegari, Saeed Sadigh-Eteghad, Maryam Saghafi-Asl,