کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8339001 1541012 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum
چکیده انگلیسی

- Androgen deprivation therapy (ADT) is an effective treatment for prostate cancer.
- We present a method for quantification of free and conjugated keto-androgens using SID-LC/ESI/SRM/MS.
- This method was validated using standards set by the United States Food and Drug Administration (US FDA).
- This was applied to patients enrolled in the Targeted Androgen Pathway Suppression (TAPS) clinical trial.
- The method can be used to interrogate personalized response and resistance to ADT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 138, November 2013, Pages 281-289
نویسندگان
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