کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8451233 | 1547693 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis
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کلمات کلیدی
HFRNAFLDMUFASFAeNOSSCD1Stearoyl-CoA desaturase 1 - استارویل-کاپا دساتوراز 1docosahexaenoic acid - اسید داکوزاگزوائونیکsaturated fatty acid - اسید چرب اشباع شدهPolyunsaturated fatty acid - اسید چرب غیر اشباعmonounsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعDiabetes - بیماری قندnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیSteatosis - تغییر چرب یا استئاتوز CHOP - تکه کردنDHA - دوکوساهگزائنوئیک اسیدRetinoid - رتینوئیدDietary fat - رژیم چاقیendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالendoplasmic reticulum - شبکه آندوپلاسمی High fructose - فروکتوز بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Previously, we reported that vitamin A deficiency resulted in the reduction of stearoyl-CoA desaturase 1 (SCD1) and monounsaturated fatty acid (MUFA) levels, which corroborated with attenuation of high fructose-induced hepatic steatosis. Here, we aimed at assessing the effect of vitamin A deficiency on SCD1, MUFA levels and their impact on pancreas' structure and functions. Male weanling Wistar rats fed one of the four diets, namely control (Con), vitamin A-deficient (VAD), highfructose (HFr) and vitamin A-deficient diet with highfructose (VADHFr) for 16 weeks period. Compared to the control, feeding of VAD diet (alone or with HFr) resulted in pancreatic intra-islet vessel dilation and reduced plasma insulin, glucagon and C-peptide levels, however, glucose levels decreased only in VADHFr group. In line with plasma levels, VAD diet-fed animals displayed lower immunostaining for insulin and glucagon, which corroborated with increased apoptotic staining observed in the islet regions, possibly due to increased cellular stress, as indicated by high immunostaining for endothelial nitric oxide synthase (eNOS) and CCAAT/Enhancer-binding protein homologues protein (CHOP). On the other hand, it significantly decreased the SCD1 protein, which corroborated with reduced MUFA levels, particularly, oleic acid (C18:1), when compared to the control and HFr groups. In conclusion, chronic vitamin A deficiency altered the structure and functions of pancreas by diminishing the islet cells, possibly by inducing cellular stress-mediated apoptosis and decreasing SCD1-mediated oleic acid (C18:1) synthesis. Thus, the data suggest that unlike liver, the reduction in SCD1 and MUFA levels in the pancreas exerts deleterious effects on its functions and perturb the overall cellular metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 364, Issue 1, 1 March 2018, Pages 104-112
Journal: Experimental Cell Research - Volume 364, Issue 1, 1 March 2018, Pages 104-112
نویسندگان
M. Raja Gopal Reddy, S. Mullapudi Venkata, U.K. Putcha, S.M. Jeyakumar,