کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513360 | 1556494 | 2018 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigations on the Mechanism of Magnesium Stearate to Modify Aerosol Performance in Dry Powder Inhaled Formulations
ترجمه فارسی عنوان
بررسی مکانیسم استایران منیزیم برای اصلاح عملکرد آئروسل در فرمولاسیون پودر خشک
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کلمات کلیدی
AFMBlending methodMGSTAPSDSPAMSNGIIGCAPIDPIFPFTof-SIMS - TOF-SIMSMagnesium stearate - استایران منیزیمAerodynamic particle size distribution - توزیع اندازه ذرات آیرودینامیکیRelative humidity - رطوبت نسبیSalmeterol xinafoate - سلمترول سیناپواتNext generation impactor - ضربه گیر نسل بعدیTime-of-Flight Secondary Ion Mass Spectrometry - طیف سنجی جرم یونی ثانویه زمان پروازTime-of-flight secondary ion mass spectrometry (TOF-SIMS) - طیف سنجی جرمی ثانویه ثانویه (TOF-SIMS)Fca - فاکسFluticasone propionate - فلوتیکازون پروپیوناتSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیActive Pharmaceutical Ingredient - مواد اولیه دارویی فعالScanning electron microscopy - میکروسکوپ الکترونی روبشیatomic force microscopy - میکروسکوپ نیروی اتمیDispersibility - پراکندگیDry powder inhaler - پودر خشک پودرDry powder inhaler (DPI) - پودر خشک پودر (DPI)high performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراInverse gas chromatography - کروماتوگرافی گاز معکوسFine particle fraction - کسر ذرات جامد
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The potential of the force control agent magnesium stearate (MgSt) to enhance the aerosol performance of lactose-based dry powder inhaled (DPI) formulations was investigated in this study. The excipient-blends were investigated with analytical techniques including time-of-flight secondary ion mass spectrometry and single particle aerosol mass spectrometry (SPAMS), and particle size, morphology, and surface properties were evaluated. Excipient-blends were manufactured either by high-shear or low-shear blending lactose carrier with different amounts of MgSt in the range from 0% to 10% (w/w). Fluticasone propionate (FP) and salmeterol xinafoate (SX) used as model active pharmaceutical ingredients were added by low-shear mixing. The in vitro aerosol performance in terms of aerodynamic particle size distribution and fine particle fraction (FPF) of the FP and SX DPI formulations was evaluated with the Next Generation Impactor and also with SPAMS using a Breezhaler® inhalation device. The distribution of MgSt on the lactose carrier in the blends was visualized and found to depend strongly on the blending method. This affected drug particle detachment from the carrier and thus impacted aerosol performance for FP and SX. Compared with blends without force control agent, low-shear blending of MgSt increases the FPF of the model drug SX, whereas high-shear blending significantly increased FPF of both SX and FP. The interactions between drug and carrier particles were substantially affected by the choice of blending technique of MgSt with lactose. This allows detailed control of aerosol performance of a DPI by an adequate choice of the blending technique. SPAMS successfully demonstrated that it is capable to distinguish changes in DPI formulations blended with different amounts of MgSt, and additional information in terms of dispersibility of fine particles could be generated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 4, April 2018, Pages 984-998
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 4, April 2018, Pages 984-998
نویسندگان
Martin W. Jetzer, Marcel Schneider, Bradley D. Morrical, Georgios Imanidis,