کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8646177 1570072 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic polymorphism in ADRB-1 is associated with type 2 diabetes susceptibility in Iranian population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Genetic polymorphism in ADRB-1 is associated with type 2 diabetes susceptibility in Iranian population
چکیده انگلیسی
β1-Adrenegic receptor (ADRB-1) leads to increase both renin and ghrelin secretions which are considered to be two hormones associated with type 2 diabetes mellitus (T2D) and insulin resistance. So, to clarify the possible impact of ADRB-1 variant in T2D, we investigated rs1801253C/G (Arg38Gly) polymorphism in a sample of Iranian population. This case-control study was carried out in 500 unrelated Iranian subjects that used Tetra amplification refractory mutation system polymerase chain reaction (Tetra ARMS-PCR) for genotyping rs1801253C/G variant. The finding demonstrated a strong association between rs1801253C/G polymorphism and T2D in versus inherited models (GG vs. CC, OR = 2.88, CI = 1.44-5.78, p = 0.003; G vs. C OR = 1.87, CI = 1.31-2.67, p = 0.0006; CG + GG vs. CC OR = 1.64 CI = 1.06-2.500 p = 0.024; and GG vs. CC + CG OR = 2.78, CI = 1.41-5.56, p = 0.0021). Our findings suggest that ADRB-1 rs1801253C/G polymorphism was prominently associated with T2D in Iranian subjects. These remarkable results needed to evaluate in other investigations with larger sample sizes and different ethnicities to confirm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Reports - Volume 12, September 2018, Pages 171-174
نویسندگان
, , , , , ,