کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8716082 | 1587877 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Risk of Incident Liver Disease in Patients with Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis: A Population-Based Study
ترجمه فارسی عنوان
خطر ابتلا به بیماری کبدی در بیماران مبتلا به پسوریازیس، آرتریت روماتوئید و آرتریت روماتوئید: یک مطالعه مبتنی بر جمعیت
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کلمات کلیدی
NAFLDAHRPSApsoriatic arthritis - آرتریت پسوریاتیکRheumatoid arthritis - آرتریتروماتوئیدPSO - بهینه سازی ازدحام ذراتNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیSystemic therapy - سیستمیک درمانbody mass index - شاخص توده بدنBMI - شاخص توده بدنیThe Health Improvement Network - شبکه بهبود سلامتconfidence interval - فاصله اطمینانTHIN - لاغرhazard ratio - نسبت خطرadjusted hazard ratio - نسبت خطر تنظیم شده استGeneral practitioner - پزشک عمومیPsoriasis - پسوریازیس
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
چکیده انگلیسی
Relatively little is known about the risk for incident liver disease in psoriasis (PsO), psoriatic arthritis (PsA), and rheumatoid arthritis (RA). We performed a cohort study among patients with PsO, PsA, or RA and matched controls in The Health Improvement Network from 1994 to 2014. Outcomes of interest were any liver disease, nonalcoholic fatty liver disease, and cirrhosis (any etiology). Among patients with PsO (NÂ = 197,130), PsA (NÂ =Â 12,308), RA (NÂ = 54,251), and matched controls (NÂ = 1,279,754), the adjusted hazard ratios for any liver disease were elevated among patients with PsO (without systemic therapy [ST] 1.37; with ST 1.97), PsA (without ST 1.38; with ST 1.67), and RA without an ST (1.49) but not elevated in patients with RA prescribed an ST (0.96). Incident nonalcoholic fatty liver disease was highest in patients with PsO prescribed an ST (2.23) and PsA with an ST (2.11). The risk of cirrhosis was highest among patients with PsO with an ST (2.62) and PsA without an ST (3.15). Additionally, the prevalence of liver disease and cirrhosis increased in a stepwise fashion with increasing body surface area affected by PsO (P for trend <0.001). More so than RA, PsO and PsA are associated with liver disease, particularly nonalcoholic fatty liver disease and cirrhosis, and this was true even among patients without ST exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 4, April 2018, Pages 760-767
Journal: Journal of Investigative Dermatology - Volume 138, Issue 4, April 2018, Pages 760-767
نویسندگان
Alexis Ogdie, Sungat K. Grewal, Megan H. Noe, Daniel B. Shin, Junko Takeshita, Zelma C. Chiesa Fuxench, Rotonya M. Carr, Joel M. Gelfand,