کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8736377 | 1591137 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic variation and systemic lupus erythematosus: A field synopsis and systematic meta-analysis
ترجمه فارسی عنوان
تنوع ژنتیکی و لوپوس اریتماتیک سیستمیک: خلاصه ای از زمینه و متاآنالیز سیستماتیک
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کلمات کلیدی
nuclear factor kappa light chain enhancer of activated B cellsTNFFalse positive report probabilityNF-κBCNVsFPRPABFTLRVNTRnatural killer - (سلول های) کشنده طبیعیinterferon - اینترفرونIFN - اینترفرون هاVariable number of tandem repeats - تعداد متغیر تکرارهای tandemToll-like receptor - تیالآرRelative risk - خطر نسبیIdentification - شناساییconfidence interval - فاصله اطمینانtumor necrosis factor - فاکتور نکروز تومورMeta-analysis - فرا تحلیل Systemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکMHC - مجموعه سازگاری بافتی اصلیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیGenome-wide association studies - مطالعات مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومodds ratio - نسبت شانس هاGene variant - نوع ژنSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدCopy number variations - کپی تغییرات شماره
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Systemic lupus erythematosus (SLE) is a multi-systemic severe autoimmune disease which results from the irreversible loss of self-tolerance and impaired molecular responses, especially an altered interferon signature. We synthesized all meta-analyses reporting a genetic association of SLE, and further investigated their validity to discover false positive results under Bayesian methods. We executed a PubMed search to extract the respective results regarding gene polymorphisms of SLE, published until June 30th 2017 and selected a single result per genetic variant among duplicates. Among 133 significant genotype comparisons, 45 (34%) were found noteworthy under both false positive report probability (FPRP) and Bayesian false discovery probability (BFDP). From the meta-analysis of genome-wide association studies (GWAS), we could confirm that all significant comparisons were noteworthy under both Bayesian approaches. Both approaches may be advantageous for determining whether the reported associations are genuine, especially for interpreting results from observational studies instead of GWAS whose significance was determined in a more strict manner. When determining results from GWAS with a p-value ranging between 0.05 and 5â¯Ãâ¯10â8, other statistical approaches, rather than single standard significance may be beneficial. Taking into account these considerations, a proportion of meta-analyses claimed statistical significance, but these results need to be interpreted with caution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 17, Issue 6, June 2018, Pages 553-566
Journal: Autoimmunity Reviews - Volume 17, Issue 6, June 2018, Pages 553-566
نویسندگان
Dong Yeon Jeong, Sang Woo Lee, Young Ha Park, Ji Hoon Choi, Young Wook Kwon, Gabin Moon, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin,