کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016399 | 1128094 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokines, stressors, and clinical depression: Augmented adaptation responses underlie depression pathogenesis
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کلمات کلیدی
5-HIAAConcanavalin-AIL-1βMitogen responseIL-10HPCPFCIL-2IL-6LPSIL-1RAIL-1αTNFα5-HT5-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدNmi - NMIinterleukin-1 receptor antagonist - آنتاگونیست گیرنده اینترلوکین-1Physiological stress - استرس فیزیولوژیکSprague–Dawley - اسپراگ داولیDepression - افسردگیinterleukin - اینترلوکینInterleukin-10 - اینترلوکین 10interleukin-6 - اینترلوکین ۶interleukin-1 alpha - اینترلوکین-1 آلفاInterleukin-1 beta - اینترلوکین-1 بتاInterleukin-2 - اینترلوکین-۲tumor necrosis factor alpha - تومور نکروز عامل آلفاexploration - جهانگردی یا اکتشافLocomotion - حرکتImmune system - دستگاه ایمنی یا سیستم ایمنیBehavior - رفتارOpen-field behavior - رفتار بازserotonergic - سروتونرژیکSerotonin - سروتونینCytokines - سیتوکین هاHabituation - عادی شدن یا خوگیریPsychological stress - فشار روانیNanotechnology - فناوری نانوprefrontal cortex - قشر prefrontallocus coeruleus - لوکوس سیرولئوسlipopolysaccharide - لیپوپلی ساکاریدHypothalamus-pituitary-adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالSprague–Dawley rats - موش Sprague-DawleyFawn Hooded rats - موش صحراییHPA - میلی بار یا هکتوپاسکالNoradrenergic - نورآدرنژیکnorepinephrine - نوراپی نفرینNeurochemistry - نورو شیمیHippocampus - هیپوکامپ Voltammetry - ولتامتری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
By influencing the central nervous system, cytokines, which regulate immune function innately and adaptively, may play a key role in mediating depression-like neuro-behavioral changes. However, the similarity between cytokine and stressor-effects in animal models raises a question about the degree to which behavioral and neurochemical outcomes of cytokine challenge represent depressive disorder per se. The present review attempts to illustrate the degree of overlap between cytokines and stressors with respect to their effects on neurochemistry and behavior in animal models. The review also shows how short-term effects of cytokine exposure in typical animals may be discerned from characteristics that might otherwise be described as depression-like. By comparing outcomes of immune challenge in typical rodent strains (e.g., Sprague-Dawley [SD], Wistar) and an accepted animal model of depression (e.g., Fawn Hooded [FH] rodent strain), differences between short-term effects of cytokines and depression-like characteristics in rodents are demonstrated. Additionally, because it is known that preexisting vulnerability to depression may affect outcomes of immune challenge, we further compare immunological, biochemical and behavioral effects of cytokines between SD and FH rodent strains. Interestingly, the acute neurochemical and behavioral effects of the cytokine interleukin 1α (IL-1α) reveal stressor-like responses during behavioral habituation in both strains, though this appears to a stronger degree in FH animals. Further, the subacute response to IL-1α vastly differed between strains, indicating differences in adaptive mechanisms. Thus, stressor-like effects of immune challenge, particularly in FH animals, provide validation for recent “cross-sensitization” models of depression pathogenesis that incorporate immune factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 5, June 2005, Pages 793-807
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 5, June 2005, Pages 793-807
نویسندگان
Donn A. Simmons, Patricia A. Broderick,