کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
907266 | 1472904 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear
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کلمات کلیدی
cpsCPUDorsal PAGcFosBLAmGluRRVMVLMdPAGPAGCeA - CEADMSO - DMSOventrolateral - ventrolateralSAL - WILLphosphate buffer - بافر فسفاتlateral ventricle - بطن جانبی3rd ventricle - بطن سومConditioned fear - ترس متعادلFear conditioning - تهدید ترسPain - دردDimethylsulfoxide - دیمتیل سولفواکسیدrostral ventromedial medulla - روستال ونتومدیال مدولاRIM - ریمRimonabant - ریمونابانت، آکومپلیاSaline - سالینdentate gyrus - شکنج دندانه دارForm - فرمFormalin - فرمالینventrolateral medulla - مدول ونتیلاتورcentral nucleus of the amygdala - هسته مرکزی آمیگدالbasolateral nucleus of the amygdala - هسته نزولی amygdalaCaudate putamen - پاتامن CaudateCannabinoid - کانابینوئیدcingulate cortex - کورتکس کانگولتMetabotropic glutamate receptors - گیرنده های متابوتروپیک گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
The basolateral amygdala (BLA) contains a high density of cannabinoid CB1 receptors and is critically involved in pain and fear-related behaviour. We investigated the effects of bilateral intra-BLA administration of the CB1 receptor antagonist/inverse agonist, rimonabant, on formalin-evoked nociceptive behaviour, fear-conditioned behaviour including analgesia, and associated brain regional alterations in Fos expression in rats. Intra-BLA administration of rimonabant significantly reduced formalin-evoked nociceptive behaviour in the absence, but not presence, of conditioned fear. Rimonabant attenuated a formalin-evoked reduction in freezing while emitting 22Â kHz ultrasonic vocalisation in the early part of the fear expression trial. Formalin-evoked nociceptive behaviour was associated with increased Fos immunoreactivity (FI) in the CA2/3 region of the hippocampus and rostral ventromedial medulla, effects attenuated by intra-BLA rimonabant. Formalin also decreased FI in the cingulate cortex, an effect which was not observed in fear-conditioned rats. Contextually-induced fear was associated with increased FI in the dorsal caudal periaqueductal grey in the absence, but not presence, of formalin-evoked nociceptive tone. In conclusion, bilateral intra-BLA administration of rimonabant reduces nociceptive behaviour in a model of tonic, persistent inflammatory pain, an effect associated with reduced activation of neurons in the CA2/3 hippocampus and rostral ventromedial medulla. The data also provide evidence for differential pain- and fear-related brain regional activity in the presence or absence of contextually-induced aversion and nociceptive tone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pain - Volume 14, Issue 5, May 2010, Pages 487-495
Journal: European Journal of Pain - Volume 14, Issue 5, May 2010, Pages 487-495
نویسندگان
Michelle Roche, Patrick Johnston, Orla NÃ Mhuircheartaigh, Weredeselam M. Olango, Kenneth Mackie, David P. Finn,