Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response

Exposure to human IgE in vitro in the absence of known specific antigen can enhance chemokine production by human mast cells, and this secretory response can be enhanced by preincubation of the mast cells with IL-4 and can be suppressed by dexamethasone.