کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9230444 | 1203635 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bivalent Effect of UV Light on Human Skin Mast Cells-Low-Level Mediator Release at Baseline but Potent Suppression Upon Mast Cell Triggering
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
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![عکس صفحه اول مقاله: Bivalent Effect of UV Light on Human Skin Mast Cells-Low-Level Mediator Release at Baseline but Potent Suppression Upon Mast Cell Triggering Bivalent Effect of UV Light on Human Skin Mast Cells-Low-Level Mediator Release at Baseline but Potent Suppression Upon Mast Cell Triggering](/preview/png/9230444.png)
چکیده انگلیسی
Ultraviolet (UV) irradiation is an established treatment for inflammatory skin diseases, although the precise mode of action is still unclear. Activating and suppressive effects on mast cell (MC) mediator release have been described. The aim of this study was to investigate systematically the effects of UVB, UVA-1, and psoralen plus UVA-1 at therapeutic doses on skin-derived human MC. Baseline and stimulated release of histamine, tryptase, and of interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-α) were examined. In resting MC, UV light induced a slight, yet significant histamine release corresponding to enhanced surface levels of lysosome-associated membrane proteins (LAMP). In contrast, UV pre-treatment caused a marked suppression of the anti-IgE-induced histamine release, accompanied by a diminished, anti-IgE-mediated increase in LAMP expression. The secretion of IL-6, IL-8, and TNF-α was inhibited in resting and activated MC, suggesting a different mode of action. Regarding the importance of MC in a variety of allergic and inflammatory processes, our data show a high susceptibility of this cell type towards UV light, which seems to partially depend on the state of cellular activation. Immunosuppressive effects predominate in activated MC, thus corresponding with the beneficial effects in inflammatory diseases, whereas in resting MC, both stimulatory and inhibitory effects are observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 124, Issue 2, February 2005, Pages 453-456
Journal: Journal of Investigative Dermatology - Volume 124, Issue 2, February 2005, Pages 453-456
نویسندگان
Sven Guhl, Richard Stefaniak, Marc Strathmann, Magda Babina, Helmut Piazena, Beate M. Henz, Torsten Zuberbier,