کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9273873 | 1221245 | 2005 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Insulin-secreting cells derived from stem cells: Clinical perspectives, hypes and hopes
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کلمات کلیدی
ASCsbiobreeding ratTGF-βLIFGvHDSSEAEnsaNonobese diabetic mouseZDF ratINF-γECCSIGRPESCsCTLA4EBsFADDGADNFATiNOSGFPglutamic acid decarboxylase - glutamic acid dearboxylaseinterferon-γ - اینترفرون-γinterleukin - اینترلوکینDiabetes - بیماری قندtransforming growth factor-β - تبدیل فاکتور رشد βInsulin secretion - ترشح انسولینtumour necrosis factor-α - تومور نکروز عامل αIslets of Langerhans - جزایر لانگرهانسembryoid bodies - جنین های جنینیSOD - سدStem cells - سلول های بنیادیAdult stem cells - سلول های بنیادی بالغEmbryonic stem cells - سلولهای بنیادی جنینیEmbryonal carcinoma cells - سلولهای کارسینومای Embryonalinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییMitochondrial superoxide dismutase - سوپراکسید دیسموتاز میتوکندریleukaemia inhibitory factor - عامل مهارکننده لوکمیnuclear factor of activated T-cells - عامل هسته سلول های فعال شده فعال استTNF-α - فاکتور نکروز توموری آلفاmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیNOD mouse - موس NODBB rat - موش BBZucker diabetic fatty rat - موش چرب دیابتی زوکرNitric oxide - نیتریک اکسیدgreen fluorescent protein - پروتئین فلورسنت سبزTransplantation - پیوندGraft versus host disease - پیوند در برابر بیماری میزبان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Diabetes is a degenerative disease that results from the selective destruction of pancreatic β-cells. These cells are responsible for insulin production and secretion in response to increases in circulating concentrations of nutrients, such as glucose, fatty acids and amino acids. This degenerative disease can be treated by the transplantation of differentiated islets obtained from cadaveric donors, according to a new surgical intervention developed as Edmonton protocol. Compared to the classical double transplant kidney-pancreas, this new protocol presents several advantages, concerning to the nature of the implant, immunosuppressive drug regime and the surgical procedure itself. However, the main problem to face in any islet transplantation program is the scarcity of donor pancreases and the low yield of islets isolated (very often around 50%) from each pancreas. Nevertheless, transplanted patients presented no adverse effects and no progression of diabetic complications. In the search of new cell sources for replacement trials, stem cells from embryonic and adult origins represent a key alternative. In order to become a realistic clinical issue transplantation of insulin-producing cells derived from stem cells, it needs to overcome multiple experimental obstacles. The first one is to develop a protocol that may allow obtaining a pure population of functional insulin-secreting cells as close as possible to the pancreatic β-cell. The second problem should concern to the transplantation itself, considering issues related to immune rejection, tumour formation, site for implant, implant survival, and biosafety mechanisms. Although transplantation of bioengineered cells is still far in time, experience accumulated in islet transplantation protocols and in experiments with appropriate animal models will give more likely the clues to address this question in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 15, Issue 2, December 2005, Pages 113-129
Journal: Transplant Immunology - Volume 15, Issue 2, December 2005, Pages 113-129
نویسندگان
Enrique Roche, Juan Antonio Reig, Adolfo Campos, Beatriz Paredes, John R. Isaac, Susan Lim, Roy Y. Calne, Bernat Soria,