کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9890035 | 1539998 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Telomere dysfunction in aging and cancer
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کلمات کلیدی
human telomerase RNADNA-PKcsHTRDSBSCIDNHEJALTAPChTERT - htertDNA damage - آسیبDNATelomere dysfunction - اختلال در تلومرGenomic instability - بی ثباتی ژنوم Telomeres - تلومرهاTumorigenesis - تومورزاییdouble-strand breaks - شکست دو ردیفAlternative lengthening of telomeres - طولانی شدن جایگزین تلومرهاHomologous recombination - نوترکیبی همولوگDNA-dependent protein kinase catalytic subunit - وابسته به DNA وابسته به پروتئین کیناز کاتالیزوریNonhomologous end joining - پیوستن به انتهای غیرخطیadenomatous polyposis coli gene - ژن کولیت پولیپوز آدنوماتوزsevere combined immunodeficiency - کمبود شدید مصدوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Telomere dysfunction in aging and cancer Telomere dysfunction in aging and cancer](/preview/png/9890035.png)
چکیده انگلیسی
Telomeres are unique DNA-protein structures that contain noncoding TTAGGG repeats and telomere-associated proteins. These specialized structures are essential for maintaining genomic integrity. Alterations that lead to the disruption of telomere maintenance result in chromosome end-to-end fusions and/or ends being recognized as double-strand breaks. A large body of evidence suggests that the cell responds to dysfunctional telomeres by undergoing senescence, apoptosis, or genomic instability. In conjunction with other predisposing mechanisms, the genomic instability encountered in preimmortal cells due to dysfunctional or uncapped telomeres might lead to cancer. Furthermore, telomere dysfunction has been proposed to play critical roles in aging as well as cancer progression. Conversely, recent evidence has shown that targeting telomere maintenance mechanisms and inducing telomere dysfunction in cancer cells by inhibiting telomerase can lead to catastrophic events including rapid cell death and increased sensitivity to other cancer therapeutics. Thus, given the major role telomeres play during development, it is important to continue our understanding telomere structure, function and maintenance. Herein, we provide an overview of the emerging knowledge of telomere dysfunction and how it relates to possible links between aging and cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 37, Issue 5, May 2005, Pages 1000-1013
Journal: The International Journal of Biochemistry & Cell Biology - Volume 37, Issue 5, May 2005, Pages 1000-1013
نویسندگان
David Gilley, Hiromi Tanaka, Brittney-Shea Herbert,