
Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer
Keywords: HNC; head and neck cancer; DCA; dichloroacetate; CDDP; cisplatin; OXPHOS; oxidative phosphorylation; PDK2; pyruvate dehydrogenase kinase 2; PDHE1α; pyruvate dehydrogenase isoform E1α; ROS; reactive oxygen species; ÎΨm; mitochondrial membrane potential