Hepatocytes: The powerhouse of biotransformation
Keywords: hepatocytes; Hepatocytes; Biotransformation enzymes; Phase I metabolism; Phase II metabolism
مقالات ISI hepatocytes (ترجمه نشده)
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Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Keywords: hepatocytes; In vitro/in vivo; Hepatocytes; Metabolic clearance; Permeability; Diffusion
Effects of ready to drink teas on AhR- and PXR-mediated expression of cytochromes P450 CYP1A1 and CYP3A4 in human cancer cell lines and primary human hepatocytes
Keywords: hepatocytes; AhR; aryl hydrocarbon receptor; CYP; cytochrome P450; GR; glucocorticoid receptor; HepG2; human Caucasian hepatocellular carcinoma cell line; LS174T; human colon tumour cell line; PXR; pregnane X receptor; RDT; ready to drink tea; RIF; rifampicin; TCDD; 2
Autoinduction of the metabolism of phenothiazine neuroleptics in a primary culture of human hepatocytes
Keywords: hepatocytes; phenothiazine neuroleptics; metabolism; autoinduction; human cytochrome P450; hepatocytes
Enantioselective metabolism and cytotoxicity of the chiral herbicide ethofumesate in rat and chicken hepatocytes
Keywords: hepatocytes; Ethofumesate; Stereoselective metabolism; Stereoselective cytotoxicity; Hepatocytes
An operational concept for long-term cinemicrography of cells in mono- and co-culture under highly controlled conditions – The SlideObserver
Keywords: hepatocytes; Time lapse; Cinemicrography; Hepatocytes; Coculture; Bioreactor
In vitro evaluation of co-exposure of arsenium and an organic nanomaterial (fullerene, C60) in zebrafish hepatocytes
Keywords: hepatocytes; Fullerene; Arsenic; Glutathione-S-transferase omega; Hepatocytes; Zebrafish;
Biotransformation of flavonols and taxifolin in hepatocyte in vitro systems as determined by liquid chromatography with various stationary phases and electrospray ionization-quadrupole time-of-flight mass spectrometry
Keywords: hepatocytes; Flavonols; Flavanonol; Taxifolin; Metabolism; Liquid chromatography; Retention behaviour; Mass spectrometry; Hepatocytes;
Effects of flavored mineral waters on AhR-CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells
Keywords: hepatocytes; AhR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; MW; mineral water; PXR; pregnane X receptor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; Cell lines; Cytochrome P450; Food-drug interaction; Hepatocytes; Mineral waters;
Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract
Keywords: hepatocytes; Gynostemma pentaphyllum; Hepatocytes; Free fatty acids; Diabetes mellitus; Lipotoxicity
Nonalcoholic fatty liver disease is associated with an altered hepatocyte microRNA profile in LDL receptor knockout mice
Keywords: hepatocytes; MicroRNA; Hepatocytes; Liver steatosis; Nonalcoholic fatty liver disease; Lipid metabolism; Fasting
Adenosine A1 receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes
Keywords: hepatocytes; Adenosine A1 receptor; Lipogenesis; Expression profiling; qPCR; Radioligand binding; Hepatocytes;
Ethnically diverse pluripotent stem cells for drug development
Keywords: hepatocytes; ethnic diversity; genomic diversity; liver toxicity; induced pluripotent stem cells; hepatocytes; drug development; post-marketing drug failure
Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs
Keywords: hepatocytes; in vitro-in vivo correlations (IVIVC); hepatocytes; microsomes; clearance; intrinsic clearance; protein binding; prediction; precision; bias;
Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes
Keywords: hepatocytes; Cruciferous vegetable; Sulforaphane; Selenium; Thioredoxin reductase; Dietary supplement; Hepatocytes;
Induction of cytochrome P4501A by highly purified hexachlorobenzene in primary cultures of ring-necked pheasant and Japanese quail embryo hepatocytes
Keywords: hepatocytes; Hexachlorobenzene; Dioxin; Cytochrome P4501A; EROD; Hepatocytes; mRNA expression;
The role of cell types in cytomegalovirus infection in vivo
Keywords: hepatocytes; Herpesvirus; Cell tropism; Pathogenesis; Endothelial cells; Hepatocytes; Conditional mutagenesis; Cre-recombinase; Transgenic mice; Dissemination; Viraemia; Immunogenicity; Immune evasion
Interaction of Listeria monocytogenes autolysin amidase with glycosaminoglycans promotes listerial adhesion to mouse hepatocytes
Keywords: hepatocytes; Autolysin amidase; Glycosaminoglycan; Adhesion; Hepatocytes; Ami; autolysin amidase of L. monocytogenes; BSA; bovine serum albumin; CWA; cell wall anchoring; Îami; Ami-deficient mutant of L. monocytogenes; DMEM; Dulbecco's modified eagle medium; GAG(s);
Characterization of Hepatic Cellular Uptake of α1-Acid Glycoprotein (AGP), Part 2: Involvement of Hemoglobin β-Chain on Plasma Membranes in the Uptake of Human AGP by Liver Parenchymal Cells
Keywords: hepatocytes; alpha 1-acid glycoprotein; glycoproteins/glycoprotein receptors; hepatocytes; protein binding; hepatic transport;
Research ArticleGeneration of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction
Keywords: hepatocytes; FOXA2; HNF1α; Hepatocytes; Adenovirus; Drug screening; Drug metabolism; hESCs; hiPSCs;
Induction of oxidative stress by selenomethionine in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss)
Keywords: hepatocytes; Selenomethionine; Hepatocytes; Oxidative stress; Intracellular calcium; Thiol redox; Apoptosis;
Human and rat hepatocyte toxicity and protein phosphatase 1 and 2A inhibitory activity of naturally occurring desmethyl-microcystins and nodularins
Keywords: hepatocytes; Cyanobacteria; Hepatocytes; Liver toxicity; Microcystins; Nodularin; Protein phosphatases
Down-regulation of Polη expression leads to increased DNA damage, apoptosis and enhanced S phase arrest in L-02 cells exposed to hydroquinone
Keywords: hepatocytes; Hydroquinone; Hepatocytes; DNA damage; RNA interference; Cell cycle; Apoptosis
The new murine hepatic 3A cell line responds to stress stimuli by activating an efficient Unfolded Protein Response (UPR)
Keywords: hepatocytes; Cellular model; Hepatocytes; ER stress; RBP4;
Characterization of desoxymethyltestosterone main urinary metabolite produced from cultures of human fresh hepatocytes
Keywords: hepatocytes; Desoxymethyltestosterone; Metabolites; Synthesis; Hepatocytes; GC–MS
La activación de receptor activado por proliferadores peroxisómicos β/δ mejora la resistencia a insulina inducida por IL-6 en células hepáticas
Keywords: hepatocytes; Resistencia a insulina; PPARβ/δ; Hepatocitos; Insulin resistance; PPARβ/δ; Hepatocytes;
Redox homeostasis and posttranslational modifications/activity of phosphatase and tensin homolog in hepatocytes from rats with diet-induced hepatosteatosis
Keywords: hepatocytes; Hepatocytes; Hepatosteatosis; Glutathione; Oxidative stress; PTEN
Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line
Keywords: hepatocytes; ABC, ATP-binding cassette; AhR, aryl-hydrocarbon receptor; CAR, constitutive androstane receptor; IVM, ivermectin; MLs, macrocyclic lactones; P-gp, P-glycoprotein; PXR, pregnane X receptorIvermectin; Macrocyclic lactones; P-glycoprotein; Mdr1; Hepatocytes
Elucidation of the metabolic pathway of S-equol in rat, monkey and man
Keywords: hepatocytes; HT; hormone therapy; WHI; Women's Health Initiative; LC-RAM-MS; liquid chromatography-radioactivity monitor-mass spectrometry; MS/MS; tandem mass spectrometry; TIC; total ion content; XIC; extracted ion chromatograms; HPLC; high pressure liquid
Role of biomaterials, therapeutic molecules and cells for hepatic tissue engineering
Keywords: hepatocytes; Hepatocytes; Extracellular matrix; Scaffold; Growth factor; Galactose; Trans-differentiation
Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model
Keywords: hepatocytes; biliary excretion; hepatobiliary disposition; drug interactions; in vitro-in vivo correlations (IVIVC); hepatic clearance; permeability; transporters; hepatocytes;
Safety evaluation of stem cells used for clinical cell therapy in chronic liver diseases; with emphasize on biochemical markers
Keywords: hepatocytes; Stem cell; Hepatocytes; Safety evaluation; Biochemical; Molecular markers
A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes
Keywords: hepatocytes; hepatic clearance; hepatic metabolism; hepatocytes; metabolic clearance; CYP enzymes; cytochrome P450; clearance; flavin monooxygenases (FMO);
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells
Keywords: hepatocytes; AA; ascorbic acid; BSO; buthionine-(S,R)-sulfoximine; DEM; diethylmaleate; DHA; dehydroascorbic acid; qPCR; quantitative real-time RT-PCR; Ascorbic acid; Glutathione; SVCT1; SVCT2; Hepatoma cells; Hepatocytes;
Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes
Keywords: hepatocytes; ALT; alanine aminotransferase; AST; aspartate aminotransferase; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma protein 2; Bcl-xL; B-cell lymphoma-extra-large; BUN; blood urea nitrogen; caspase 3; cysteine-aspartic protease 3; COL1-α1; collagen t
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: Effects of cytochrome P450 induction by phenobarbital
Keywords: hepatocytes; Genotoxicity; N-Nitrosodiethylamine; Hepatocytes; Phenobarbital; Cytochrome P450 isoforms;
Detection of free radicals formed by in vitro metabolism of fluoride using EPR spectroscopy
Keywords: hepatocytes; Fluoride; Fluorosis; Free radicals; EPR spectroscopy; Hepatocytes;
Modulation of cytochrome P450 gene expression in primary hepatocytes on various artificial extracellular matrices
Keywords: hepatocytes; ASGPR; asialoglycoprotein receptor; BAL; bioartificial liver; BSA; bovine serum albumin; CYP; cytochrome P450; DAPI; 4â²,6-diamidino-2-phenylindole; E-cad-Fc; E-cadherin-IgG Fc; ECM; extracellular matrix; EGF; epidermal growth factor; Mrp2; multidrug res
Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells
Keywords: hepatocytes; Drug metabolism; Cell line; Hepatocytes; Cytochrome P450;
Assessment of a novel β2-adrenoceptor agonist, trantinterol, for interference with human liver cytochrome P450 enzymes activities
Keywords: hepatocytes; Trantinterol; Drug–drug interactions; Cytochrome P450; Human liver microsomes; Hepatocytes
Protective effects of fucoxanthin against ferric nitrilotriacetate-induced oxidative stress in murine hepatic BNL CL.2 cells
Keywords: hepatocytes; Fe-NTA; ferric nitrilotriacetate; BNL CL.2; murine embryonic hepatocytes; TBARS; thiobarbituric acid-reactive substances; Fucoxanthin; Ferric nitrilotriacetate; Oxidative damage; Antioxidant; Hepatocytes;
Toxic responses in primary rat hepatocytes exposed with occupational dust collected from work environment of bone-based industrial unit
Keywords: hepatocytes; Occupational dust; TSPM; Hepatocytes; Cytotoxicity; Lactate dehydrogenase; Lipid peroxidation
The glucose transporter-2 (GLUT2) is a low affinity dehydroascorbic acid transporter
Keywords: hepatocytes; Dehydroascorbic acid; Vitamin C; GLUTs; SVCTs; Hepatocytes; H4IIE cells
Protective effects of melittin on transforming growth factor-β1 injury to hepatocytes via anti-apoptotic mechanism
Keywords: hepatocytes; Melittin; TGF-β1; Hepatocytes; Apoptosis; Liver disease
Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver
Keywords: hepatocytes; disposition; elimination; endothelial; protein binding; surfactants; pharmacokinetics/pharmacodynamics; hepatocytes; hepatic metabolism; hepatic clearance; disposition
Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes
Keywords: hepatocytes; PET; Fluorine-18; Fluoroaniline; Metabolism; Quinazoline; EGFR; Hepatocytes
Reversible metabolic depression in lamprey hepatocytes during prespawning migration: Dynamics of mitochondrial membrane potential
Keywords: hepatocytes; Hepatocytes; Lamprey; Mitochondrial membrane potential; Prespawning migration
Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity
Keywords: hepatocytes; DCF, 2′,7′-dichlorofluorescein; DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; EDTA, ethylenediaminetetraacetic acid disodium salt dehydrate; GSH, glutathione; LDH, lactate dehydrogenase; VPA, valproic acidCytotoxicity; Glutathione; Hepatocytes; Oxida
Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes
Keywords: hepatocytes; Genomics; 2,3,7,8-TCDD; 2,3,7,8-TCDF; 2,3,4,7,8-PeCDF; Hepatocytes; CYP1A
Impact of metals on histopathology and expression of HSP 70 in different tissues of Milk fish (Chanos chanos) of Kaattuppalli Island, South East Coast, India
Keywords: hepatocytes; Heavy metal; Sediment; Chanos chanos; Hepatocytes; HSP70