N-acetyl cysteine reduces chromosomal DNA damage in circulating lymphocytes during cardiac catheterization procedures: A pilot study
Keywords: Ionizing radiation; NAC; DNA damage;
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N-acetylcysteine (NAC) Protects Against Acute Kidney Injury (AKI) Following Prolonged Pneumoperitoneum in the Rat
Keywords: pneumoperitoneum; AKI; glomerular filtration rate; NAC; oxidative stress
Notes techniques relatives à la mastectomie pratiquée dans le cadre du transsexualisme F à M
Keywords: Mastectomie; Transsexualisme; Plastie masculinisante de la PAM; PAM; Greffe de la PAM; Plaque aréolo-mammelonnaire (PAM)Mastectomy; Transsexualism; NAC; NAC plasty
N-acetylcysteine reverses existing cognitive impairment and increased oxidative stress in glutamate transporter type 3 deficient mice
Keywords: EAAT; excitatory amino acid transporter or glutamate transporter; ELISA; enzyme-linked immunosorbent assay; GSSG; glutathione disulfide; HNE; 4-hydroxy-2-nonenal; NAC; N-acetylcysteine; cognitive functions; glutamate transporter 3; glutathione; mice; oxid
The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells
Keywords: ROS; reactive oxygen species; IFN; interferon; ISGs; interferon stimulated genes; NAC; N-acetylcysteine; FACS; fluorescence activated cell sorting; UBP43; USP18; Ubiquitin-like protein; ISG15; Interferon-α/β; Apoptosis; Mitochondrial pathway; Reactive o
Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1
Keywords: CPG; carboxyphenylglycine; CGN; cerebellar granular neurons; CHX; cycloheximide; DCF; dichlorodihydrofluorescein; GSHME; glutathione monoethyl ester; ICP-MS; inductively-coupled plasma mass spectrometry; LDH; lactate dehydrogenase; MeHg; methylmercury; MR
MethodsConstruction and validation of a GFP-based vector for promoter expression analysis in the fish pathogen Flavobacterium psychrophilum
Keywords: A525; absorvance at 525 nm; ANOVA; analysis of variance; cfu; colony-forming unit; DNA; deoxyribonucleic acid; FRU; fluorescence relative unit; GFP; green fluorescent protein; MCS; multiple cloning site; NA; nutrient agar; NAC; nutrient agar charcoal; NB;
Pathogenesis of Liver Injury in Acute Liver Failure
Keywords: ALF; acute liver failure; ALFSG; US Acute Liver Failure Study Group; APAP; acetaminophen; DAMP; damage-associated molecular pattern; DILI; drug-induced liver injury; GWAS; genome-wide association study; HMGB-1; high-mobility group box-1; IL; interleukin;
Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells
Keywords: PDT; photodynamic therapy; ROS; reactive oxygen species; FDA; Food and Drug Administration; PhB; phloxine B; IFN; interferon; FBS; fetal bovine serum; NAC; N-acetyl-l-cysteine; H2DCF-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; JNK; c-Jun-N-termina
Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism
Keywords: Juglone; Reactive oxygen species; NAC; Apoptosis; HL-60;
Reduced expression of the mu opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G
Keywords: A118G; knock-in mouse; mu opioid receptor; N-glycosylation; autoradiography; A/A; homozygous for A112 allele; CPu; caudate putamen; G/G; homozygous for G112 allele; MeCP2; methyl-CpG-binding protein 2; MOPR; mu opioid receptor; NAc; nucleus accumbens; OPR
The Nucleus Accumbens as a Potential Target for Central Poststroke Pain
Keywords: CPSP; central poststroke pain; DBS; deep brain stimulation; ECT; electroconvulive therapy; ICL; intercommissural line; MCS; motor cortex stimulation; NAC; nucleus accumbens; PFC; prefrontal cortex; PVG; periventricular gray region; VC; ventralis caudalis
Dithiocarbamate fungicide zineb induces oxidative stress and apoptosis in Chinese hamster lung fibroblasts
Keywords: Glutathione; Lipid peroxidation; Protein oxidation; Topoisomerase I; NAC
Cytotoxicity induced by deltamethrin and its metabolites in SH-SY5Y cells can be differentially prevented by selected antioxidants
Keywords: 3-PBA; 3-Phenoybenzoic acid; NO; nitric oxide; NAC; N-acetylcysteine; MEL; melatonin; MDA; malondialdehyde; TBARS; thiobarbituric acid reactive substance; DMSO; dimethylsulfoxide; SDS; sodium dodecyl sulfate; EMEM; Eagle´s minimum essential medium; FBS;
Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation
Keywords: 5-HT; serotonin; ADHD; Attention-Deficit/Hyperactivity Disorder; DA; dopamine; i.p.; intra-peritoneally; eCB; endocannabinoid; mPFC; medial prefrontal cortex; NAC; nucleus accumbens; NE; norepinephrine; VTA; ventral tegmental area; Endogenous cannabinoid
Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides
Keywords: Acylase 1; Mercapturate metabolites; Mycotoxins; Detoxification; Ac; acetyl; ACY-1; acylase 1; Enzyme: aminoacylase-1; N-acyl-l-amino acid amidohydrolase 1 (EC 3.5.1.14); NAM; N-acetyl-l-methionine; N-acetyl-cysteine; NAC; pACY1; porcine aminoacylase-1; h
Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells
Keywords: aSMase; acid sphingomyelinase; AA; arachidonic acid; BSA; bovine serum albumin; C1P; ceramide-1-phosphate; CerK; ceramide kinase; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; DAPI; 4,6-diamidino-2-phynelindole; DCF; dichlorofluorescein; DOPE; 1
Research ArticleMitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
Keywords: ASH; alcoholic steatohepatitis; AA; antimycin A; HP; 3-hydroxy-4-pentenoate; GSHee; GSH ethyl ester; GSHPx1; GSH peroxidase 1; mGSH; mitochondrial GSH; MCD; methionine-choline deficient diet; MRC; mitochondrial respiratory chain; NAC; N-acetylcysteine; NA
Tianeptine exerts neuroprotective effects in the brain tissue of rats exposed to the chronic stress model
Keywords: AMY; amygdala; CAT; catalase; CS; chronic stress; HPC; hippocampus; IL-6; interleukin-6; IL-1; interleukin-1; MDA; malondialdehyde; LPS; lipopolysaccharide; MDD; major depressive disorder; NAc; nucleus accumbens; PFC; prefrontal cortex; RNS; reactive nitr
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice
Keywords: AMN082; N,Nâ²-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride; BEC; blood ethanol concentrations; CPP; conditioned place preference; mGluR; metabotropic glutamate receptor; MMPIP; 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin
Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice
Keywords: CPA; conditioned place aversion; DA; dopamine; NA; noradrenaline; 5-HT; serotonin; NAc; nucleus accumbens; VTA; ventral tegmental area; TH; tyrosine hydroxylase; NTS-A2; nucleus of the solitary tract, noradrenergic cell group; 5-HIAA; 5-hydroxyindolacetic
Scaffold protein Homer 1: Implications for neurological diseases
Keywords: EVH1; Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1; IEG; immediate-early gene; P motif; proline-containing motif; mGluR; metabotropic glutamate receptor; IP3R; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potentia
Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation
Keywords: APD; action potential duration; CAMKII; Ca2Â +/calmodulin-dependent protein kinase II; CL; cycle length; DEP; diesel exhaust particles; EAD; early afterdepolarization; NAC; N-acetylcysteine; PM; particulate matter; ROS; reactive oxygen species; VT; ventri
Hypoxia, Mn-SOD and H2O2 regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells
Keywords: DN-mutant p53 R175H; dominant-negative mutant p53 Arg 175His; wt; wild type; PARP; poly(ADP-ribose) polymerase; [Mn-SOD, SOD2]; manganese-dependent superoxide dismutase; [Cu/Zn-SOD, SOD1]; copper-zinc-dependent superoxide dismutase; BSO; buthionine sulf
p38MAPK and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y
Keywords: AMS; 4-acetamido-4-maleimidylstilbene-2,2-disulfonic acid; ARE; antioxidant response elements; BSO; buthionine sulfoximine; DMSO; dimethyl sulfoxide; DMTU; dimethylthiourea; DN Nrf2; dominant negative Nrf2 protein; DNP; 2,4-dinitrophenylhydrazine; ERK1/2;
Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury
Keywords: ROS; reactive oxygen species; MAPK; mitogen-activated protein kinase; PAECs; porcine aorta endothelial cells; GSH; glutathione; NAC; N-acetylcysteine; BSO; l-buthionine-(S,R)-sulfoximine; DPPP; diphenyl-1-pyrenylphosphine; WST-8; 2-(2-methoxy-4-nitropheny
Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation
Keywords: AK; ankaflavin; AREs; antioxidant response elements; BALF; bronchoalveolar lavage fluid; CAT; catalase; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescent; ESI-MS; electrospray ionization-mass spectrometry; FBS; fetal bovine serum; GABA; γ-aminob
The NAC transcription factor gene ANAC072 is differentially expressed in Arabidopsis thaliana in response to microbe-associated molecular pattern (MAMP) molecules
Keywords: Arabidopsis; Biotic stress; Flagellin; Innate immunity; Lipopolysaccharides; NAC; Peptidoglycan; Transcription factor
Dual effects of N-acetyl-l-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity
Keywords: BSFGE; biased sinusoidal field gel electrophoresis; DCFH-DA; 6-carboxy-2, 7â²-diclorodihydrofluorescein diacetate, di(acetoxymethyl ester); DCPIP; 2,6-dichlorophenol-indophenol; DSBs; double strand breaks; DTT; dithiothreitol; GSH; glutathione; γ-H2AX;
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity
Keywords: CHOP; C/EBP homologous protein; DDIT3; DNA damage inducible transcript 3; FACS; fluorescence activated cell sorter; FRET; Förster resonance energy transfer; NAC; n-acetylcysteine; Organometallic; Anticancer; Caspase 8; ROS; Ruthenium;
A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells
Keywords: 3BDO; 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one; VEC; vascular endothelial cell; LPS; lipopolysaccharide; HUVECs; human umbilical vein endothelial cells; ROS; reactive oxygen species; MMP; mitochondrial membrane potential; JC-1; 5,5â²,6
Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?
Keywords: UVB; Ultraviolet B; NAC; N-acetyl-L-cysteine; ROS; reactive oxygen species; JNK; c-Jun-NH2-kinase; PDMP; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol; AMPK; AMP-activated protein kinas; ACC; Acetyl-CoA carboxylase; mTOR; Mammalian target of rapamycin;
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species
Keywords: I/RP; ischemia/reperfusion; EC; endothelial cell; mtROS; mitochondrial reactive oxygen species; H/RO; hypoxia/reoxygenation; Drp1; dynamin-related protein 1; O2â¢â; superoxide; eNOS; endothelial nitric oxide synthase; ETC; electron transport chain; ONO
Synthesis of the 3-sulfates of S-acyl glutathione conjugated bile acids and their biotransformation by a rat liver cytosolic fraction
Keywords: BAs; bile acids; CoA; coenzyme A; GSH; glutathione; NAC; N-acetylcysteine; LC; liquid chromatography; ESI; electrospray ionization; MS; mass spectrometry; CA-GSH; S-(cholyl)glutathione; CDCA-GSH; S-(chenodeoxycholyl) glutathione; DCA-GSH; S-(deoxycholyl)
The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis
Keywords: I6; 1-(3,4-dimethoxyphenyl)-3,5-dodecenedione; Vit E; vitamin E; NAC; N-acetylcysteine; ROS; reactive oxygen species; PARP; poly(ADP-ribose)polymerase; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; FCCP; carbonyl cyanide p-(trifluoromethoxy)phe
Antioxidants counteract lipopolysaccharide-triggered alterations of human colonic smooth muscle cells
Keywords: α-TLR4; antagonist antibody to TLR4; F-actin; filamentous actin; G-actin; globular actin; GSH; glutathione; HCSMC; human colonic smooth muscle cells; IL; interleukin; LPS; lipopolysaccharide; MMP; mitochondrial membrane potential; NAC; N-acetylcysteine;
Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study
Keywords: ANOVA; one-way analysis of variance; BLA; basolateral nucleus of amygdala; BSA; bovine serum albumin; BZ; benzodiazepine; CA1; CA1 pyramidal cell layer of the hippocampus; CA3; CA3 pyramidal cell layer of the hippocampus; CeL; lateral division of the cent
Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax
Keywords: DCF; 2â²,7â²-dichlorofluorescein; MEF; mouse embryonic fibroblasts; MMP-2; matrix metalloproteinase-2; NAC; N-acetyl-cysteine; PI3K; phosphoinositide 3-kinase; ROS; reactive oxygen species; Bcl-2 family; Cell death; Cell invasion;
Transcriptome-wide survey and expression analysis of stress-responsive NAC genes in Chrysanthemum lavandulifolium
Keywords: ABA; abscisic acid; AP2/EREBP; Apetala-2/EREBP; ATAF; arabidopsis transcription factor-like family; GO; gene ontology; MTF; membrane-bound transcription factor; MYB; myeloblastosis; NAC; NAM; ATAF; and CUC; NAP; NAC-like activated by APETALA3/PISTILLATA f
Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation
Keywords: hTERT; human telomerase reverse transcriptase catalytic subunit; hTR; human telomerase RNA component; ROS; reactive oxygen species; TNF-α; tumor necrosis factor-α; NAC; N-acetyl-L-cysteine; CHX; cycloheximide; ERK1/2; extracellular signal-regulated kina
H2O2 signals via iron induction of VL30 retrotransposition correlated with cytotoxicity
Keywords: ERV; endogenous retrovirus; enRT; endogenous reverse transcriptase; LTR; long terminal repeat; PSF; polypyrimidine tract-binding protein-associated splicing factor; MoMLV; Moloney murine leukemia virus; PBS; primer binding site; PPT; polypurine track; ROS
Research ArticleMolecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
Keywords: ALF; acute liver failure; ALI; acute liver injury; ALT; alanine aminotransferase; APAP; acetaminophen; DILI; drug-induced liver injury; HMGB1; High Mobility Group Box-1 protein; KCC; Kings College Criteria; K18; keratin-18; LFT; liver function test; NAC;
Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress
Keywords: MAPK; mitogen activated protein kinase; JNK; Jun-activated kinase; ER; endoplasmic reticulum; eIF2α; eukaryotic initiation factor 2-alpha; Gadd153/CHOP; growth arrest- and DNA damage-inducible gene 153 or C/EBP homologous protein (CHOP); ATF; activating
Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
Keywords: HepG2 cells; human hepatoblastoma cancer cell line; ROS; reactive oxygen species; NO; nitric oxide; mPTP; mitochondrial permeability transition pore; MMP; mitochondrial membrane potential; PARP; poly (ADP-ribose) polymerase; NAC; N-acetylcystein; 1400W; N
Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells
Keywords: ROS; reactive oxygen species; GSH; glutathione; NAC; N-acetylcysteine; BSO; l-d-buthionine sulfoximine; Cer; d-erythro-ceramide; SMS; sphingomyelin synthase; GCS; glucosyl ceramide synthase; PBS; phosphate-buffered saline; PARP; poly(ADP-ribose) polymeras
Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38
Keywords: AKT/PKB; protein kinase B; AP-1; activator protein-1; ARE; antioxidant response element; CHX; cycloheximide; DAPI; 6-diamidino-2-phenylindole; DTT; dithiothreitol; ERK; extracellular regulated kinase; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phosp
In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals
Keywords: Nicotinic receptors; AMPA receptors; Nicotine treatment; Neurotransmitter release; Isolated nerve endings; Nucleus accumbens; ACh; acetylcholine; AMPA; alfa-amino-3-hydroxy-5-methyl-4-isoxazolone propionate; DA; dopamine; DAT; dopamine transporter; ECL; e
Mechanisms involved in alternariol-induced cell cycle arrest
Keywords: H2DFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; JC-1; 5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolylcarbocyanineiodide; 7-ADD; 7-amino actinomycin; 8-oxoGua; 8-oxo-7,8-dihydroguanine; AOH; alternariol; AME; alternariol monomethyl e
Modulation of CD40-activated B lymphocytes by N-acetylcysteine involves decreased phosphorylation of STAT3
Keywords: ERK; extra-signal-regulated kinases; FCB; fluorescent cell barcoding; JAK3; Janus Kinase 3; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MFI; median fluorescence intensity; NAC; N-acetylcysteine; ROS; Reactive Oxygen Species; ST
Modulatory effects of low-dose hydrogen peroxide on the function of human plasmacytoid dendritic cells
Keywords: 7-AAD; 7-aminoactinomycin-D; DC; dendritic cell; ELISPOT; enzyme-linked immunospot; FCS; fetal calf serum; H2DCFDA; 2â²,7â²-dihydrodichlorofluorescein diacetate; ICOS-L; inducible costimulator ligand; IFN; interferon; mAb; monoclonal antibody; NAC; N-ac