دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration

Keywords: GAP; GTPase activating protein; GGA3; golgi-localized, γ-ear-containing Arf-binding protein 3; HA; hemagglutinin; PBD; p21-binding domain; PI3K; phosphatidylinositol (3)-kinase; PIP3; phosphatidylinositol (3,4,5) trisphosphate; ARF; Rac; Cell migration;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Midkine exacerbates pressure overload-induced cardiac remodeling

Keywords: TAC; transverse aortic constriction; ERK; extracellular signal-regulated kinase; MHC; myosin heavy chain; PI3K; phosphatidylinositol 3-kinase; ANP; atrial natriuretic peptide; BNP; brain natriuretic peptide; CTGF; connective tissue growth factor; GAPDH; g

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Insulin and IGF-I actions on IGF-I receptor in seminiferous tubules from immature rats

Keywords: IGF-IR; insulin-like growth factor 1 receptor; IR; insulin receptor; α-[1-14C], [14C]MeAIB; methylaminoisobutyric acid; 2-[1-14C], [14C]2DG; deoxy-d-glucose; PI3K; phosphatidylinositol 3-kinase; IRS-1; insulin receptor substrate 1; IRS-2; insulin recepto

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

A critical role for the regulation of Syk from agglutination to aggregation in human platelets

Keywords: Agglucetin; Convulxin; Glycoprotein Ibα; Integrin αIIbβ3; Syk; ADAP; adhesion and degranulation promoting adapter protein; FcRγ; Fc receptor γ-chain; FITC; fluorescein isothiocyanate; GP; glycoprotein; LAT; linker for activation of T-cells; mAb; mono

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity

Keywords: PH; pleckstrin homology; PI3K; phosphatidylinositide 3-kinase; PIP3; phosphatidylinositol 3,4,5-trisphosphate; mTORC2; mammalian target of rapamycin complex 2; PDK1; phosphoinositide-dependent kinase 1; FasL; Fas ligand; GFP; green fluorescent protein; KO

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Metformin modulates PI3K and GLUT4 expression and Akt/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin

Keywords: Endometrial stromal cells; Metformin; Insulin; Akt; PI3K; GLUT4;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells

Keywords: MTT; 3-[4,5-Dimethylthylthiazol-2-yl]-2,5 diphenyltetrazolium bromide; FACS; fluorescence-activated cell sorting; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; 4E-BP1; 4E-binding protein; OD; optical density; IP; imm

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Differential effects of angiotensin II receptor blockers on Aβ generation

Keywords: ARBs; angiotensin II receptor blockers; AD; Azheimer's disease; Aβ; amyloid β-protein; AT1a; angiotensin type 1a receptor; ACE; angiotensin converting enzyme; MEFs; mouse embryonic fibroblasts; hAPP695; human 695-amino acid amyloid precursor protein; AP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Astrogliosis as a therapeutic target for neurodegenerative diseases

Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BB14®; nerve growth factor-like peptide; BDNF; brain-derived neurotrophic factor; Ca2+; calcium; CNS; central nervous system; COX-1/2; cyclooxygenase-1/2; EAAC1; ex

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase

Keywords: Quercetin; Cell invasion; Cell migration; MMP-2; PI3K;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

microRNA-7: A tumor suppressor miRNA with therapeutic potential

Keywords: ACK1; activated CDC42 kinase 1; Akt; V-Akt murine thymoma viral oncogene homolog; BCL-2; B-cell CLL/lymphoma 2; CCNE1; cyclin E1; ciRS-7; circular RNA sponge 7; c-Myc; V-Myc avian myelocytomatosis viral oncogene homolog; EGFR; epidermal growth factor rece

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The role of wogonin in controlling SOCS3 expression in neuronal cells

Keywords: Wogonin; SOCS3; Neuroinflammation; PI3K; AP1; STAT3;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction

Keywords: ACh; acetylcholine; nAChR; nicotinic acetylcholine receptor; cyt c; cytochrome c; DhβE; dihydro-β-erythroidine; MLA; methyllycaconitine; MPTP; mitochondria permeability transition pore; CaMKII; calcium-calmodulin-dependent kinase; PI3K; phosphatidylinos

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Signalling pathways involved in antitumoral effects of VIP in human renal cell carcinoma A498 cells: VIP induction of p53 expression

Keywords: VIP; PI3K; VEGF; p53; Renal cell carcinoma;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components

Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/interferon γ-induced MuRF-1 expression in C2C12 cells

Keywords: FoxO; forkhead box class O; HMB; β-Hydroxy-β-methylbutyrate; IFN-γ; interferon γ; mTOR; mammalian target of rapamycin; MuRF-1; muscle RING-finger protein-1; PI3K; phosphatidylinositol 3-kinase; TNF-α; tumor necrosis factor-α; β-Hydroxy-β-methylbut

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Blockage of Stat3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition

Keywords: Akt; Bim; CHOP; mTOR; PI3K; Stat3;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Integrin αvβ3 mediates the synergetic regulation of core-binding factor α1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signaling

Keywords: IGF-1; Insulin-like growth factor 1; IRS1; insulin receptor substrate 1; OSE2; Osteoblast-Specific Element 2; HG; hypergravity; SMG; simulated microgravity; Cbfa1; core-binding factor alpha 1; PI3K; phosphoinositide 3-kinase; co-IP; co-immunoprecipitation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways

Keywords: DHM; dihydromyricetin; mTOR; mammalian targets of rapamycin; ERK1/2; extracellular signal-regulated kinase 1/2; AMPK; AMP-activated kinase; PI3K; class III phosphatidylinositol 3-kinase; PDK 1; phosphoinositide-dependent protein kinase 1; Akt; protein kin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

A monoterpene, unique component of thyme honeys, induces apoptosis in prostate cancer cells via inhibition of NF-κB activity and IL-6 secretion

Keywords: NF-κB; nuclear factor-kappaB; mapk; mitogen-activated protein kinase; PI3K; phosphatidylinositide 3-kinase; Akt; protein kinase B; FAK; focal adhesion kinase; PSG; prostate-specific G-protein-coupled receptor; IL-6; interleukin-6; JNK; c-Jun NH(2)-termin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Resveratrol prevents neuronal apoptosis in an early brain injury model

Keywords: Resveratrol; Subarachnoid hemorrhage; Early brain injury; Apoptosis; PI3K; Akt

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling

Keywords: ANOVA; analysis of variance; CUL7; Cullin7; CRL7; Cullin RING E3 ubiquitin ligase 7; FBXW8; F-box/WD repeat-containing protein 8; GLUT4; glucose transporter 4; HSP90; heat shock protein 90; IRS; insulin receptor substrate; IGF-1; insulin-like growth hormo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3

Keywords: AR, androgen receptor; ECL, enhanced chemiluminescence; HPLC, high performance liquid chromatography; LHRH, luteinizing hormone releasing hormone; mTOR, mammalian target of rapamycin; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PI3K

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Upstream and downstream mechanisms for the promoting effects of IGF-1 on differentiation of spermatogonia to primary spermatocytes

Keywords: Insulin growth factor I (IGF1); IGF1 receptor (IGF1R); Spermatogenesis; Differentiation; Spermatogonia; Primary spermatocytes; Let-7; ERK1/2; PI3K

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway

Keywords: Akt; FASN; Her2; PI3K; Resveratrol; SKBR-3;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Status of PI3K/Akt/mTOR Pathway Inhibitors in Lymphoma

Keywords: Akt; Lymphoma; mTor; PI3K; Review; Signalling; Targeted; Therapy;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Advances in subunits of PI3K class I in cancer

Keywords: Amplification; inhibitors; mutation; PI3K; subunit; tumourigenesis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

A calpain-cleaved fragment of β-catenin promotes BCRABL1 + cell survival evoked by autophagy induction in response to imatinib

Keywords: ULK1; unc-51-like kinase; ATG; autophagy-related proteins; FIP200; focal adhesion interacting protein 200; PI3K; class III phosphoinositide 3-kinase; Vps; vacuolar protein sorting; LC3; microtubule-associated protein 1 light chain 3; PE; phosphatidylethan

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway

Keywords: EMT; epithelial-mesenchymal transition; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; PI3K; phosphatidylinositide 3-kinases.; Epithelial-mesenchymal transition; Epidermal growth facto

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Integrin linked kinase (ILK) regulates podosome maturation and stability in dendritic cells

Keywords: ILK; Dendritic cell; Podosome; WASP; PI3K;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

Keywords: PI3K; MEK; KRAS; Colorectal cancer; Mouse model of cancer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

IFN-γ-induced IL-27 and IL-27p28 expression are differentially regulated through JNK MAPK and PI3K pathways independent of Jak/STAT in human monocytic cells

Keywords: IL-27; Jak/STAT; MAPK; PI3K; IFN-γ

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells

Keywords: GEF; guanine nucleotide exchange factor; T-CVID; T cell type common variable immunodeficiency; B-CLL; B-cell chronic lymphocytic leukemia; shRNA; short-hairpin RNA; SDS-PAGE; SDS-polyacrylamide gel electrophoresis; GST; Glutathione S-transferase; PAK1; p2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Cyclic phosphatidic acid and lysophosphatidic acid induce hyaluronic acid synthesis via CREB transcription factor regulation in human skin fibroblasts

Keywords: BSA; bovine serum albumin; 2ccPA; 2-carba-cPA; ChIP; chromatin immunoprecipitation; CMF-PBS; calcium- and magnesium-free PBS; CRE; cyclic adenosine monophosphate response element; cPA; cyclic phosphatidic acid; CREB; CRE binding protein; ERK; extracellula

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Exhaustive exercise increases the TNF-α production in response to flagellin via the upregulation of toll-like receptor 5 in the large intestine in mice

Keywords: TLR5; RAW264; Caco2; Epinephrine; PI3K

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportTreadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways

Keywords: S; sham-operated; M; model; EM; exercise and model; IM; inhibitor and model; IEM; inhibitor, exercise, and model; MCAO; middle cerebral artery occlusion; VEGF; vascular endothelial growth factor; VEGFR-2; VEGF receptor-2; PI3K; the phosphatidyl inositol-3

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations

Keywords: Endometrial Carcinoma Recurrence Score; ECARS; PI3K; Epithelial-mesenchymal transition; Prognosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Research ReportSquamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models

Keywords: PD; Parkinson's disease; PI3K; phosphoinositide-3-kinase; α-Syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; TH; tyrosine hydroxylase; Co-IP; Co-Immunoprecipitation; FLZ; Parkinson's disease; Akt; α-synuclein; Tyrosine hydroxylase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Halofuginone improves muscle-cell survival in muscular dystrophies

Keywords: CMD; congenital MD; DMD; Duchenne MD; ECM; extracellular matrix; ERK; extracellular signal-regulated protein kinase; DAPI; 4′,6-diamidino-2-phenylindole; MAPK; mitogen-activated protein kinase; MDs; muscular dystrophies; PI3K; phosphoinositide 3 kinase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleRapamycin and everolimus facilitate hepatitis E virus replication: Revealing a basal defense mechanism of PI3K-PKB-mTOR pathway

Keywords: mTOR; mammalian target of rapamycin; HEV; hepatitis E virus; PI3K; phosphatidylinositol-3 kinase; PKB; protein kinase B; 4E-BP1; eIF4E-binding protein 1; Hepatitis E virus; Rapamycin; Everolimus; PI3K-PKB-mTOR pathway;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Phytic acid and myo-inositol support adipocyte differentiation and improve insulin sensitivity in 3T3-L1 cells

Keywords: Phytic acid; Myo-inositol; Insulin sensitivity; Adipogenesis; Glucose uptake; 3T3-L1 cells; 2-NBDG; 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose; ANOVA; analysis of variance; C/EBP; CCAAT/enhancer-binding protein; DMEM; Dulbecco's modi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways

Keywords: AKT/PKB; protein kinase B; DCF; dichorofluorescein; DHBA; 2,3-dihydroxybenzoic acid; DHPAA; 3,4-dihydroxyphenylacetic acid; ERK; extra cellular regulated kinase; GSIS; glucose-stimulated insulin secretion; HPPA; 3-hydroxyphenylpropionic acid; KRB; Krebsâ€

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes

Keywords: Sesn2; sestrin2; ARE; antioxidant response element; t-BHQ; tert-butylhydroquinone; ROS; reactive oxygen species; Nrf2; NF-E2-related factor-2; GCS; γ-glutamylcysteine synthetase; HO-1; hemeoxygenase 1; NQO1; NAD(P)H:quinone reductase; ERK1/2; extracellul

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Molecular and cellular pharmacologyThe dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1

Keywords: EMT; Epithelial-mesenchymal transition; Hif; hypoxia inducible factor; HRE; Hif-responsive elements; ILK; Integrin-linked kinase; mTOR; Mammalian Target of Rapamycin; PI3K; Phosphatidyl Inositol 3-kinase; RTV; relative tumor volume; TGF; Transforming gr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibitory effect of a novel naphthoquinone derivative on proliferation of vascular smooth muscle cells through suppression of platelet-derived growth factor receptor β tyrosine kinase

Keywords: 2‐undecylsulfonyl‐DMNQ; 2‐undecylsulfonyl‐5,8‐dimethoxy‐1,4‐naphthoquinone; VSMC; vascular smooth muscle cell; PDGF; platelet-derived growth factor; PLC; phospholipase C; Akt/PKB; protein kinase B; STAT 3; signal transducers and activators o

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells

Keywords: Breast cancer; Migration; Invasion; Akt; PI3K

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Emerging insights into resistance to BRAF inhibitors in melanoma

Keywords: Melanoma; BRAF inhibitor; Resistance; MAPK; PI3K

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B RhoGAP

Keywords: ECM; extracellular matrix; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor (EGFR); FACS; fluorescence-activated cell sorting; FBS; fetal bovine serum; GAP; GTPase activating protein; GEF; guanine nucleotide exchange factor; IR; ionizi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Acrolein activates cell survival and apoptotic death responses involving the endoplasmic reticulum in A549 lung cells

Keywords: AFC; amino trifluorocoumarin; AKT; protein kinase B; AMC; amino methylcoumarin; ARE; antioxidant response element; ATF6; activating transcription factor-6; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid tetrakis (acetoxymethyl ester); Ba

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه