Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia
Keywords: PI3K; mTOR; Oxidative metabolism; Hypoxia; Reoxygenation;
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Nobiletin, a polymethoxy flavonoid, exerts anti-allergic effect by suppressing activation of phosphoinositide 3-kinase
Keywords: BMMC; bone marrow-derived mast cell; BSA; bovine serum albumin; [Ca2+]i; intracellular Ca2+ concentration; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulphoxide; DNP; dinitrophenol; FBS; fetal bovine serum; FcεRI; high-affinity IgE rece
miR-223: An inflammatory oncomiR enters the cardiovascular field
Keywords: AAA; Abdominal Aortic Aneurysm; AML; Acute Myeloid Leukemia; Apo-E KO; Apolipoprotein-E Knock-Out; C/EBP; CCAAT-Enhancer-Binding Proteins; CKD; Chronic Kidney Disease; D-HF; Diabetic Heart-Failure; DMD; Duchenne Muscular Dystrophy; E2F1; E2F transcription
T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28â T cells
Keywords: mTOR; mammalian target of rapamycin; mTORC1/2; mTOR complex 1/2; TCR; T cell receptor; CMV; cytomegalovirus; PI3K; phosphoinositide 3-kinase; PKB; protein kinase B; PDK; phosphoinositide-dependent protein kinase 1; S6K1; S6 kinase 1; 4E-BP1; 4E-binding pr
Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance
Keywords: AS160; Akt substrate 160; EDL; extensor digitorum longus; FWHM; Full Width at the Half Maximum; GAP; GTPase activating protein; KO; knockout; PAK1; p21 protein-activated kinase 1; PI3K; phosphatidylinositol 3-kinase; Rac1; Ras-related C3 botulinum toxin s
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages
Keywords: SAA; serum amyloid A; H3K27me3; trimethylation of histone H3 at lysine 27; HDACs; histone deacetylases; FPR2; formyl peptide receptor 2; G-CSF; granulocyte colony-stimulating factor; IL-23p19; interleukin-23 alpha subunit p19; IL-12p40; interleukin-12 p40
Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway
Keywords: Bf; free bilirubin; UCB; unconjugated bilirubin; OS; oxidative stress; ROS; reactive oxygen species; NAC; N-acetylcystein; Nrf2; NF-E2 related factor 2; ARE; Antioxidant Response Element; GSH; glutathione; xCT; cystine/glutamate exchanger system; Gly1; gl
TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway
Keywords: Mtb; Mycobacterium tuberculosis; BCG; M. bovis Bacillus Calmette-Guérin; PI3K; phosphoinositide 3-kinase; PRR; pathogen recognition receptor; TLR; Toll-like receptor; RT-PCR; reverse transcription PCR; qRT-PCR; quantitative real-time PCR; RBC; red bloo
p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks
Keywords: p70S6K; p70S6 kinase; PI3K; phosphoinositide-3-kinase; RPPA; Reverse Phase Protein Array; mTOR; mammalian target of rapamycin; MAPK; mitogen activated protein kinase; EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; RTK; receptor
Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes
Keywords: DEX; dexamethasone; ERK; extracellular signal-regulated kinases 1 and 2; eIF4E; eukaryotic initiation factor E; 4E-BP1; eIF4E-binding protein 1; FoxO; Forkhead box O Family of Transcription Factors; IGF-I; Insulin Growth Factor I; MTOR; mechanistic target
Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle
Keywords: BSA; bovine serum albumin; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; GFP; green fluorescent protein; GST; glutathione S-transferase; HA; hemagglutinin; HSA; human skeletal actin; m-rac1-KO; muscle-specific rac1 knockout; Myr
The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation
Keywords: Abp1; actin binding protein 1; BCR; B cell receptor; Btk; Bruton's tyrosine kinase; ERM; ezrin/radixin/moesin; ITAMs; immunoreceptor tyrosine-based activation motifs; mIg; membrane immunoglobulin; PI3K; phosphatidylinositol-3 kinase; PI(3,4,5)P3; phosphat
Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells
Keywords: ACC; acetyl CoA carboxylase; ACO; acyl CoA oxidase; AICAR; 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide; AMPK; adenosine monophosphate-activated protein kinase; AS160; Akt substrate 160 kDa; BSA; bovine serum albumin; CaMKII; Ca2+/calmodulin-depe
FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice
Keywords: MKP-3; MAP kinase phosphatase 3; Dex; Dexamethasone; FOXO1; forkhead box protein O1; GC; glucocorticoid; DUSP6; dual specificity protein phosphatase 6; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; PI3K; phosphoinosit
Physiological cardiac hypertrophy: Critical role of AKT in the prevention of NHE-1 hyperactivity
Keywords: Sed; sedentary, not-trained rats; Swim; swim-trained rats; CH; cardiac hypertrophy; NHE-1; Na +/H + exchanger isoform 1; ERK1/2; extracellular signal-regulated kinase 1 and 2; PI3K; phosphatidylinositol 3-kinase; p90RSK; 90 kDa ribosomal S6 protein ki
In vivo hyperoxia induces hypoxia-inducible factor-1α overexpression in LNCaP tumors without affecting the tumor growth rate
Keywords: In vivo hypoxia; In vivo hyperoxia; LNCaP tumor; Angiogenesis; Hypoxia-inducible factor; Akt; phosphatidylinositol-3-phosphate/protein kinase B; Hb; hemoglobin; HIF-1α; hypoxia-inducible factor-1α; Ki67; Antigen anti-KI-67; LNCaP; androgen-sensitive hum
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
Keywords: T-ALL; GLI1; GANT58; AKT inhibitor; Apoptosis; Hh; hedgehog; T-ALL; acute T cell leukemia; SMO; Smoothened; GLI1; GLI family zinc finger 1; SHH; Sonic hedgehog; DHH; Desert hedgehog; IHH; Indian hedgehog; PTCH1; Patched 1; PI3K; phosphatidylinositol 3-kin
Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway
Keywords: 2-Arachidonoylglycerol; Myosin light chain; RhoA/RhoA kinase; Myosin light chain phosphatase; Phosphatidylinositol 3 kinase/AKT pathway; 2-AG; arachidonoylglycerol; MLC; p20 myosin light chain; MLCK; myosin light chain kinase; MLCP; myosin light chain pho
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; 6-OHDA; 6-hydroxydopamine; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; AMPK; AMP-dependent/activated protein kinase; DAB; 3,3â²-diaminobenzidine tetrachloride; DAPI; 4â²,6-diamidino-2-
Synthesis of heteroaryl/aryl kojic acid conjugates as stimulators of glucose uptake by GLUT4 translocation
Keywords: Heteroaryl/aryl kojic acid conjugates; Insulin receptor; GLUT4 translocation; PI3K
The estrogen receptor β-PI3K/Akt pathway mediates the cytoprotective effects of tocotrienol in a cellular Parkinson's disease model
Keywords: Vitamin E; Parkinson's disease; Estrogen receptor; PI3K; Akt; Caveolin;
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
Keywords: mTOR; Akt; PI3K; Autophagy; Insulin signaling; Trisomy 21;
Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells
Keywords: AKT/PKB; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; BrdU; 5-bromo-2â²-deoxyuridine; CaMMK; Ca2+/calmodulin-dependent protein kinase kinase; CPE; cocoa phenolic extract; EC; (â)-epicatechin; EGCG; epigallocatechin gallate; ERK; extracell
Map2k4δ - Identification and functional characterization of a novel Map2k4 splice variant
Keywords: AKT; protein kinase B; ATF-2; activating transcription factor 2; BrdU; 5-bromo-2-deoxyuridine; DVD; domain of versatile docking; E; embryonic day; ERK; extracellular signal-regulated kinase; Fas-L; Fas ligand; ID; immunodepletion; IP; immunoprecipitation;
Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells
Keywords: PI3K; HS-527; Pancreatic cancer; Apoptosis; Angiogenesis
Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer
Keywords: Luminal type; Breast cancer; Phosphatidylinositol 3-kinase; PI3K; AKT; Mammalian target of rapamycin; mTOR; Estrogen receptor; Endocrine therapy; Endocrine resistance
SPA0355 suppresses T-cell responses and reduces airway inflammation in mice
Keywords: AHR; airway hyperresponsiveness; BAL; bronchoalveolar lavage; BALF; BAL fluid; CD; cluster of differentiation; CFSE; carboxyfluorescein succinimidyl ester; CsA; cyclosporine A; ERK; extracellular signal-regulated kinase; GADPH; glyceraldehyde-3-phosphate
Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1
Keywords: Ms-EE; ethanolic extract of Myrsine seguinii; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors (TLR); MAPK; mit
A novel microRNA regulates osteoclast differentiation via targeting protein inhibitor of activated STAT3 (PIAS3)
Keywords: miRNAs; microRNAs; PIAS3; protein inhibitor of activated STAT3; M-CSF; macrophage colony stimulating factor; RANKL; receptor activator of nuclear factor-κB ligand; RANK; receptor activator of NF-κB; OPG; osteoprotegerin; MAPKs; mitogen-activated protein
miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling
Keywords: miRNAs; miR-126; Dopamine neurons; Parkinson's disease; Insulin; IGF-1 signaling; PI3K; Laser capture microdissection; Postmortem; 6-OHDA neurotoxicity; Cell systems;
The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats
Keywords: DN; diabetic nephropathy; 1,25(OH)2D3; 125-dihydroxyvitamin D3; VDR; vitamin D receptor; PI3K; phosphoinositide 3-kinase; PI3K-p85; phosphoinositide 3-kinase p85 subunit; CKD; chronic kidney disease; ESRD; end-stage renal disease; STZ; streptozotocin; Cal
Insulin-sensitizing and insulin-mimetic activities of Sarcopoterium spinosum extract
Keywords: AMPK; AMP-activated protein kinase; BAD; Bcl 2-antagonist of cell death; 2-DG; 2-deoxy-d-glucose; FoxO; forkhead transcription factor; GSK3β; glycogen synthase kinase 3β; IBMX; isobutylmethylxanthine; IKK; inhibitor of nuclear factor kappa-B kinase; IR;
Fucoidan from sea cucumber protects against high-fat high-sucrose diet-induced hyperglycaemia and insulin resistance in mice
Keywords: ALT; alanine transminase; Am-FUC; fucoidan from Acaudina molpadioides; ANOVA; one-way analysis of variance; AST; aspartate aminotransferanse; AUC; area under curve; BUN; serum urea nitrogen; Cr; creatinine; ECL; superenhanced chemiluminescence; G6Pase; gl
Induction of galectin-1 by TGF-β1 accelerates fibrosis through enhancing nuclear retention of Smad2
Keywords: Gal-1; galectin-1; α-SÎÎ; smooth muscle actin-alpha; Col; collagen; BLM; bleomycin; TGF; Transforming growth factor; SBEs; Smad binding elements; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; COL1A2; α2(I)-collage
Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor
Keywords: AcP; acid phosphatase; AI; androgen-independent; AS; androgen-sensitive; cPAcP; cellular prostatic acid phosphatase; CR PCa; castration-resistant prostate cancer; DSP; dual specificity phosphatase; EGFR; epidermal growth factor receptor; HER-2/ErbB-2/neu;
Signaling pathways involved in MDSC regulation
Keywords: Myeloid derived suppressor cells (MDSC); PI3K; TGFβ; Ras; Jak/Stat; Tumor microenvironment;
Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth
Keywords: Linoleic acid; Gab1; PI3K; EGFR; Breast cancer; Lung cancer
Insight into the structural mechanism for PKBα allosteric inhibition by molecular dynamics simulations and free energy calculations
Keywords: PKB/Akt; protein kinase B; MD; molecular dynamics; PI3K; phosphatidylinostiol-3-kinase; PDK1; 3â²-phosphoinositide-dependent kinase-1; PTEN; phosphatase and tensin homolog; MM/PBSA; molecular mechanics/Poisson Boltzmann surface area; MM/GBSA; molecular m
Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication
Keywords: aCSF; artificial cerebrospinal fluid; Akt; serine/threonine protein kinase; EMSA; electrophoretic mobility shift assay; HR; heart rate; LF; low-frequency; 3-MA; 3-methyladenine; NF-κB; nuclear factor-κB; NO; nitric oxide; NOS; nitric oxide synthase; NRS
Isolation and characterization of MdATG18a, a WD40-repeat AuTophaGy-related gene responsive to leaf senescence and abiotic stress in Malus
Keywords: ATG18; AuTophaGy-related gene 18; CRL4; cullin4-RING ubiquitin ligase complex; Cvt; cytoplasm-to-vacuole targeting; DWD; DNA-binding WD40 proteins; EF-1α; elongation factor 1 alpha gene; ER; endoplasmic reticulum; MV; methyl viologen; ORF; open reading f
The intricate interplay between RNA viruses and NF-κB
Keywords: ss; single-stranded; ds; double-stranded; HTLV; human T cell leukemia virus; SARS; severe acute respiratory syndrome; IAVs; influenza A viruses; IFN; interferon; IRF3; interferon regulatory factor 3; NF-κB; nuclear factor κB; TLRs; toll-like receptors;
The structural basis for mTOR function
Keywords: mTOR; PI3K; Rapamycin; 4E-BP1; S6K1; PIKK;
Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling
Keywords: AFI; absolute fluorescence intensity; CR; complement receptors; DMSO; dimethyl sulphoxide; DLS; dynamic light scattering; ELISA; enzyme linked immunosorbent assay; FBS; fetal bovine serum; MR; mannose receptors; MAPKs; mitogen-activated protein kinases; P
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions
Keywords: AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; DCFH-DA; dichlorofluorescin diacetate; DR4; death receptor 4; ETC; electron transport chain; FBS; fetal bovine serum; HEGU; hexane/ethanol extract of Glycyrrhiza uralensis Fisch; IAA; isoangus
Activation of PKB and ERK, but not PI3K, is involved in fucosylated chondroitin sulphate from Acaudina molpadioides induced glucose uptake
Keywords: ANOVA; one-way analysis of variance; Am-CHS; fucosylated chondroitin sulphate from Acaudina molpadioides; DMEM; Dulbecco's modified eagle medium; ECL; super-enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; GLUT4; glucose transporter
Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals
Keywords: 4-HNE; 4-hydroxynonenal; 8OH-dG; 8-hydroxy-2â²deoxyguanosine; AMPK; cyclic-AMP-activated protein kinase; ARE; antioxidant response element; ATF; activating transcription factor; B[a]P; Benzo[a]pyrene; Bach1; broad-complex, tramtrack and bric a brac; CBP;
BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma
Keywords: BDNF; brain derived neurotrophic factor; TrkB; tropomyosin related kinase B receptor; APP; amyloid precursor protein; ONH; optic nerve head; GCL; ganglion cell layer; H&E; haematoxylin and eosin; RGC; retinal ganglion cells; IOP; intraocular pressure; PI3
Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC
Keywords: PI3K; NSCLC; Lung cancer; PI3K inhibition; PIK3CA; mTOR; Co-targeted inhibition; MEK; Chemoresistance; Radioresistance;
Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans
Keywords: ER; estrogen receptor; PgR; progesterone receptor; HER2/erbB2; human epidermal growth factor receptor-2; E2; estradiol; RTK; receptor tyrosine kinase; IGF-IR; insulin-like growth factor I receptor; EGFR; epidermal growth factor receptor; MAPK; mitogen act