Negative and positive masking responses to light in retinal degenerate slow (rds/rds) mice during aging
Keywords: دژنراسیون شبکیه; Aging; Locomotion; Masking; Retinal degeneration
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Retinal isoforms of inosine 5′-monophosphate dehydrogenase type 1 are poor nucleic acid binding proteins
Keywords: دژنراسیون شبکیه; Retinitis pigmentosa; IMP dehydrogenase; Retinal degeneration; Nucleic acid binding protein
Protection of retinal cells from ischemia by a novel gap junction inhibitor
Keywords: دژنراسیون شبکیه; Ischemia; Cobalt Chloride (CoCl2); Gap junctions; Retinal degeneration; Hypoxia; Caspase-3; HIF1α; PQ1;
Nanoparticle applications in ocular gene therapy
Keywords: دژنراسیون شبکیه; Nanoparticle; Ocular gene therapy; Gene transfer; Non-viral therapy; Retinal degeneration; Vector design
Retinal degeneration in children: Dark adapted visual threshold and arteriolar diameter
Keywords: دژنراسیون شبکیه; Bardet-Biedl syndrome; Leber congenital amaurosis; Usher syndrome; Dark adapted threshold; Retinal vasculature; Retinal degeneration; Rod mediated visual sensitivity
Activation of retinal ganglion cells in wild-type and rd1 mice through electrical stimulation of the retinal neural network
Keywords: دژنراسیون شبکیه; Electrical stimulation; Ganglion cell; Mouse; Threshold; rd1; Retinal degeneration
Visual function testing: A quantifiable visually guided behavior in mice
Keywords: دژنراسیون شبکیه; Activity; Masking; Methods; Mouse; Retinal degeneration; Visual function testing
Cone-specific expression using a human red opsin promoter in recombinant AAV
Keywords: دژنراسیون شبکیه; Cone; Gene therapy; Photoreceptors; Promoter; rAAV; Retina; Retinal degeneration
Experimental coronavirus retinopathy (ECOR): Retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection
Keywords: دژنراسیون شبکیه; Coronavirus; Retinal degeneration; Chemokines; Interferon; Autoimmunity
The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats
Keywords: دژنراسیون شبکیه; blood vessel development; retinal degeneration; rhodopsin mutations; transgenic; RCS; rat
Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa
Keywords: دژنراسیون شبکیه; gentamicin; premature stop codon; retinitis pigmentosa; retinal degeneration; Rd12; S334ter
Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia
Keywords: دژنراسیون شبکیه; oxidative stress; crystallins; retinal pigment epithelium; retinal degeneration; hypoxia; apoptosis
Mitochondrial DNA damage and its potential role in retinal degeneration
Keywords: دژنراسیون شبکیه; Retinal pigment epithelium; Age-related macular degeneration; Mitochondria; Base excision repair; Oxidative stress; Retinal degeneration
Composition and function of the Crumbs protein complex in the mammalian retina
Keywords: دژنراسیون شبکیه; Crumbs; CRB1; CRB2; CRB3; MPP; MAGUK; retinal degeneration; cell adhesion
Dual role of Nr2e3 in photoreceptor development and maintenance
Keywords: دژنراسیون شبکیه; Nr2e3; nuclear receptor; rd7; photoreceptor; retinal degeneration; expression profiling; microarray
Altered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitfmi and Mitfvitiligo mouse mutants
Keywords: دژنراسیون شبکیه; retinal pigment epithelium (RPE); microphthalmia-associated transcription factor (Mitf); gene expression; Nramp1 (Slc11a1); iron homeostasis; melanosome; vitiligo mouse mutant; retinal degeneration
The effect of dendritic cells on the retinal cell transplantation
Keywords: دژنراسیون شبکیه; Retinal degeneration; Transplantation; Dendritic cell; Bone marrow cell; Immune tolerance;
Microarray expression analysis of the early N-methy-N-nitrosourea-induced retinal degeneration in rat
Keywords: دژنراسیون شبکیه; Retinal degeneration; N-methy-N-nitrosourea; Animal model; Microarray analysis; Real time RT-PCR
Behavioral evaluation of visual function of rats using a visual discrimination apparatus
Keywords: دژنراسیون شبکیه; Visual discrimination; Visual threshold; Pattern detection; Retinal degeneration;
Taurine deficiency and apoptosis: Findings from the taurine transporter knockout mouse
Keywords: دژنراسیون شبکیه; Compatible organic osmolytes; Inflammation; Liver disease; Olfactory epithelium; Retinal degeneration; Retinitis pigmentosa
Long-term visual prognoses in patients with retinitis pigmentosa: The Ludwig von Sallmann lecture
Keywords: دژنراسیون شبکیه; retinitis pigmentosa; retinal degeneration; retina; cones; electroretinogram; vitamin A; genetic disease; night blindness
RdgB proteins: Functions in lipid homeostasis and signal transduction
Keywords: دژنراسیون شبکیه; RdgB; Retinal degeneration; Phosphatidylinositol; PI(4,5)P2; Diacylglycerol; Golgi; Drosophilia; Photoreceptors
Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration
Keywords: دژنراسیون شبکیه; bone marrow mesenchymal stem cell; transplantation; retinal degeneration; electroretinogram
Myelin Vacuolation, Optic Neuropathy and Retinal Degeneration after Closantel Overdosage in Sheep and in a Goat
Keywords: دژنراسیون شبکیه; closantel; goat; halogenated salicylanilides; myelin oedema; optic neuropathy; retinal degeneration; sheep; status spongiosis
Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration
Keywords: دژنراسیون شبکیه; retinal degeneration; photoreceptor degeneration; retinitis pigmentosa; rd1 mouse; neurodegeneration; antioxidants; ALA; alpha lipoic acid; AMD; age-related macular degeneration; DMSO; dimethylsulfoxide; GSH; reduced l-glutathione; H/E; hematoxylin/eosin;
Two mouse retinal degenerations caused by missense mutations in the β-subunit of rod cGMP phosphodiesterase gene
Keywords: دژنراسیون شبکیه; Mouse model; Retinal degeneration; Retinitis pigmentosa; rd1; rd10; nmf137; PDE6b; β-Phosphodiesterase; Rod photoreceptor; cGMP-PDE; β-Subunit of rod cGMP phosphodiesterase gene
Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse
Keywords: دژنراسیون شبکیه; retinal degeneration; immune response; rd1; SCID; Rag1−/−; complement system
Pathology of damaging electrical stimulation in the retina
Keywords: دژنراسیون شبکیه; retinal prosthesis; electrical stimulation; retina; retinal degeneration
FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro
Keywords: دژنراسیون شبکیه; FIZ1; NRL; CRX; rhodopsin; cGMP-phosphodiesterase β-subunit; transcription; retinal development; gene; retinal degeneration; mouse
Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function
Keywords: دژنراسیون شبکیه; retinal degeneration; knock-out model; transgenic model; photoreceptor; synapse; inner segments; outer segments
Light at the end of the tunnel? Advances in the understanding and treatment of glaucoma and inherited retinal degeneration
Keywords: دژنراسیون شبکیه; Gene therapy; Glaucoma; Neuroprotection; Retinal dystrophy; Retinal degeneration
Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet–Biedl syndrome
Keywords: دژنراسیون شبکیه; Bardet–Biedl syndrome; Retina; Retinal degeneration; Electroretinogram (ERG); Protein transport; Intraflagellar transport
Impacts of two point mutations of RPE65 from Leber’s congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65
Keywords: دژنراسیون شبکیه; CHX, cycloheximide; LCA, Leber’s congenital amaurosis; LRAT, lecithin retinol acyltransferase; MOI, multiplicity of infection; RPE, retinal pigment epithelium; ER, endoplasmic reticulumLRAT; Retinoid; Retinal degeneration; RPE; RPE65; Visual cycle
A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity
Keywords: دژنراسیون شبکیه; Rhodopsin; Photoreceptor; Retinal degeneration
Reversal of functional loss in the P23H-3 rat retina by management of ambient light
Keywords: دژنراسیون شبکیه; light management; rhodopsin; P23H; retinal degeneration
The emerging role of proteases in retinal ganglion cell death
Keywords: دژنراسیون شبکیه; retina; proteases; matrix metalloproteinases; plasminogen activators; retinal ganglion cells; retinal degeneration; and glaucoma
The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration
Keywords: دژنراسیون شبکیه; Circadian rhythm; Clock gene; Per1; Retinal degeneration; Suprachiasmatic nucleus
Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration
Keywords: دژنراسیون شبکیه; Retinal degeneration; Rhodopsin; Photoreceptor; Membrane biogenesis; Electron microscopy (EM)
Atypical gliosis in Müller cells of the slowly degenerating rds mutant mouse retina
Keywords: دژنراسیون شبکیه; K+ currents; patch-clamp methodology; retinal degeneration; Müller cell; reactive gliosis
Bright cyclic light accelerates photoreceptor cell degeneration in tubby mice
Keywords: دژنراسیون شبکیه; Retinitis pigmentosa; tubby mice, photoreceptor cells; Retinal degeneration; Light damage; Phototransduction, apoptosis; Neuronal protection
Autoantibodies to p75/LEDGF, a cell survival factor, found in patients with atypical retinal degeneration
Keywords: دژنراسیون شبکیه; Autoantibody; P75/LEDGF/DFS70; ATR-X; Retinal degeneration
Mouse models of age-related macular degeneration
Keywords: دژنراسیون شبکیه; age-related macular degeneration; choroidal neovascularization (CNV); retina; retinal degeneration; animal models; transgenicA2E, N-retinylidene-N-retinylethanolamine; AMD, age-related macular degeneration; BLD, basal laminar/linear deposits; CNV, choroid
Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans
Keywords: دژنراسیون شبکیه; Dogs; Disease models, animal; Genetic diversity; Genetic linkage; Genetic markers; Genetic predisposition to disease; Genetic variation; Mutation; Retinal degeneration; Retinitis pigmentosa;
Molecular basis of human Usher syndrome: Deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease
Keywords: دژنراسیون شبکیه; senso-neuronal disease; retinal degeneration; retinitis pigmentosa; deafness; supramolecular network; interactome
Retinal degeneration and local oxygen metabolism
Keywords: دژنراسیون شبکیه; oxygen; retinitis pigmentosa; RP; retinal degeneration; oxygen metabolism;
Measuring the cone contribution to the ERG b-wave to assess function and predict anatomical rescue in RCS rats
Keywords: دژنراسیون شبکیه; RCS rat; Retinal degeneration; Cone; Cell based therapy; ERG double flash; Pigmented Royal College of Surgeons rat; rdy+-p+;
Physiological function of S-cone system is not enhanced in rd7 mice
Keywords: دژنراسیون شبکیه; electroretinogram; mouse; Nr2e3; rd7; retinal degeneration;
Changes in glutamate receptor function in synaptic input to the superficial superior colliculus (SSC) with aging and in retinal degeneration in the Royal College of Surgeons (RCS) rat
Keywords: دژنراسیون شبکیه; Superior colliculus; Rat (Royal College of Surgeons); Retinal degeneration; Aging; NMDA receptor; Metabotropic glutamate receptor; mGlu8; Excitatory postsynaptic potentials; Retinocollicular transmission; GABA receptor; Dicarboxyphenylglycine;
Rhodopsin–EGFP knock-ins for imaging quantal gene alterations
Keywords: دژنراسیون شبکیه; Photoreceptors; Gene knock-ins; Fluorescence imaging; Confocal microscopy; Retinal degeneration; Gene therapy
Cone function studied with flicker electroretinogram during progressive retinal degeneration in RCS rats
Keywords: دژنراسیون شبکیه; RCS; rat; retinal degeneration; electroretinogram; flicker; cones;