کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10553270 967726 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant bioactive compounds in tomato fruits at different ripening stages and their effects on normal and cancer cells
ترجمه فارسی عنوان
ترکیبات آنتی اکسیدانی زیست فعال در میوه های گوجه فرنگی در مراحل مختلف رسیدن و اثرات آنها بر سلول های طبیعی و سرطانی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The changes in antioxidant content of tomato fruits at different ripening stages (mature green, breaker and mature red) were determined and hydrophilic extracts were tested on normal and cancer cells. Large differences existed in the content of bioactive compounds at different ripening stages, with breaker tomatoes containing a higher content of hydrophilic antioxidants. We demonstrated a high cytotoxic effect of α-tomatine in green, but not in breaker, tomato extracts on all cell lines analysed. Cell death was found to be an apoptotic independent mechanism, probably due to α-tomatine binding to cell membrane cholesterol, disruption of cell integrity and necrosis. These results help in understanding which harvesting stage corresponds to the highest functional power of tomato fruits and may lead to the development of tomato-based functional foods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 83-94
نویسندگان
, , , , , , ,