کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815423 | 1058473 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The epigenetic feedback loop between DNA methylation and microRNAs in fibrotic disease with an emphasis on DNA methyltransferases
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کلمات کلیدی
Mecp2Hu-antigen RSPP1DNA methyltransferasesDNMTsSOCSSOCS1HSCPPARγIPFSSCsystemic sclerosis - اسکلروز سیستمیکChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهCOPD - بیماری مزمن انسدادی ریهsecreted phosphoprotein 1 - ترشح فسفوپروتئین 1Hepatic stellate cell - سلول ستاره ای کبدیcytokine signaling - سیگنالینگ سیتوکینFibroblast - فیبروبلاستidiopathic pulmonary fibrosis - فیبروز ریوی ایدیوپاتیکFibrogenesis - فیبروژنزDNA methylation - متیلاسیون DNAMyofibroblast - میوفیبروبلاستMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAHCV - هپاتیت سیchronic hepatitis C virus - ویروس مزمن هپاتیت Cmethyl-CpG binding protein 2 - پروتئین متصل CpG متیل 2HuR - چگونهperoxisome proliferator-activated receptor γ - گیرنده پروتئین کننده پروکسیوم فعال γ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Epigenetic processes play a key regulatory role in many cancers. Recently, it also has been demonstrated to participate in fibrogenesis, especially in fibrotic disease. Fibrotic disease is a pathological response to tissue injury which can occur in any organ. Mechanisms that orchestrate fibrotic disorders in different organs are amazingly generic, involving generation of activated fibroblasts and myofibroblasts by differentiation processes that require extensive alterations in gene expression. Apart from genetic and environmental factors, epigenetic modifications including a combination of microRNAs and DNA methylation are supposed as regulatory mechanisms to control myofibroblast differentiation. It has become obvious that microRNAs, which act as regulators of gene expression at a post-transcriptional level, are differentially expressed in differentiating cells and play important roles in governing DNA methyltransferases (DNMTs) which are enzymes responsible for setting up and maintaining DNA methylation patterns at specific regions of the genome. Some microRNAs targeting DNMT transcripts lead to the demethylation and transcriptional activation of numerous protein coding gene sequences, thereby contributing to gene expression. Moreover, DNMTs also have a critical role in controlling some specific microRNA expression. This cooperative action among DNMTs, microRNAs and DNA methylation indicates that DNMTs may participate in the pathogenesis of myofibroblast differentiation through silencing of certain gene transcription. In this review, we summarize the current knowledge of a potential link between microRNA expression and DNA methylation on how DNMTs work in the process of fibrogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 25, Issue 9, September 2013, Pages 1870-1876
Journal: Cellular Signalling - Volume 25, Issue 9, September 2013, Pages 1870-1876
نویسندگان
Xu Sun, Yong He, Cheng Huang, Tao-Tao Ma, Jun Li,