کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2019394 1068598 2007 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipids in photosynthetic reaction centres: Structural roles and functional holes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Lipids in photosynthetic reaction centres: Structural roles and functional holes
چکیده انگلیسی
Photosynthetic proteins power the biosphere. Reaction centres, light harvesting antenna proteins and cytochrome b6f (or bc1) complexes are expressed at high levels, have been subjected to an intensive spectroscopic, biochemical and mutagenic analysis, and several have been characterised to an informatively high resolution by X-ray crystallography. In addition to revealing the structural basis for the transduction of light energy, X-ray crystallography has brought molecular insights into the relationships between these multicomponent membrane proteins and their lipid environment. Lipids resolved in the X-ray crystal structures of photosynthetic proteins bind light harvesting cofactors, fill intra-protein cavities through which quinones can diffuse, form an important part of the monomer-monomer interface in multimeric structures and may facilitate structural flexibility in complexes that undergo partial disassembly and repair. It has been proposed that individual lipids influence the biophysical properties of reaction centre cofactors, and so affect the rate of electron transfer through the complex. Lipids have also been shown to be important for successful crystallisation of photosynthetic proteins. Comparison of the three types of reaction centre that have been structurally characterised reveals interesting similarities in the position of bound lipids that may point towards a generic requirement to reinforce the structure of the core electron transfer domain. The crystallographic data are also providing new opportunities to find molecular explanations for observed effects of different types of lipid on the structure, mechanism and organisation of reaction centres and other photosynthetic proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 46, Issue 1, January 2007, Pages 56-87
نویسندگان
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