کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3220405 1587895 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the antioxidant status in patients of lichen planus in Kashmir valley – A hospital based study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Evaluation of the antioxidant status in patients of lichen planus in Kashmir valley – A hospital based study
چکیده انگلیسی

BackgroundLichen planus is an inflammatory skin disorder of unknown etiology. Recently, increased reactive oxygen species (ROS) and lipid peroxides have been implicated in the pathogenesis of various inflammatory dermatoses including lichen planus.AimsThe present study was designed to evaluate the oxidative stress and the antioxidant defense status in Kashmiri patients suffering from lichen planus.MethodsA total of 60 patients with lichen planus (27 males, 33 females) and 60 control subjects, matched for age and gender were enrolled in this prospective case control study. Serum levels of Superoxide dismutase (SOD), malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GPX) and Nitric oxide (NO) levels were measured in both patients and controls.ResultsPlasma levels of MDA, NO and SOD enzymes were significantly higher (p < 0.05) in patients than in controls. Plasma levels of GSH and GPX were significantly lower in patients than in controls (p < 0.05).ConclusionsThe findings in our study suggest an increased lipid peroxidation and an imbalance in the antioxidant defense mechanisms in lichen planus. This may play a role in the pathogenesis of lichen planus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Saudi Society of Dermatology & Dermatologic Surgery - Volume 17, Issue 1, January 2013, Pages 13–16
نویسندگان
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