کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4482669 1316866 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ozone treatment ameliorates oil sands process water toxicity to the mammalian immune system
موضوعات مرتبط
مهندسی و علوم پایه علوم زمین و سیارات فرآیندهای سطح زمین
پیش نمایش صفحه اول مقاله
Ozone treatment ameliorates oil sands process water toxicity to the mammalian immune system
چکیده انگلیسی

We evaluated whether ozonation ameliorated the effects of the organic fraction of oil sands process water (OSPW) on immune functions of mice. Ozonation of OSPW eliminated the capacity of its organic fraction to affect various mouse bone marrow-derived macrophage (BMDM) functions in vitro. These included the production of nitric oxide and the expression of inducible nitric oxide synthase, the production of reactive oxygen intermediates and the expression of NADPH oxidase subunits, phagocytosis, and the expression of pro-inflammatory cytokine genes. Ozone treatment also eliminated the ability of OSPW organic fraction to down-regulate the expression of various pro-inflammatory cytokine and chemokine genes in the liver of mice, one week after oral exposure. We conclude that ozone treatment may be a valuable process for the remediation of large volumes of OSPW.

Figure optionsDownload high-quality image (97 K)Download as PowerPoint slideHighlights
► Oil sands process water (OSPW) alters mammalian macrophage functions in vitro.
► OSPW causes alterations of immune gene expression in vivo.
► Ozone treatment of OSPW significantly reduced its immunotoxicity both in vitro and in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Water Research - Volume 45, Issue 18, 15 November 2011, Pages 5849–5857
نویسندگان
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