کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5646666 | 1407069 | 2016 | 11 صفحه PDF | دانلود رایگان |

BackgroundEarly introduction of peanut is an effective strategy to prevent peanut allergy in high-risk infants; however, feasibility and effects on growth and nutritional intake are unknown.ObjectiveWe sought to evaluate the feasibility of introducing peanut in infancy and explore effects on growth and nutritional intake up to age 60Â months.MethodsIn the Learning Early About Peanut Allergy trial, 640 atopic infants aged 4 to 11Â months were randomly assigned to consume (6Â g peanut protein per week) or avoid peanut until age 60Â months. Peanut consumption and early feeding practices were assessed by questionnaire. Dietary intake was evaluated with prospective food diaries. Anthropometric measurements were taken at all study visits.ResultsPeanut was successfully introduced and consumed until 60Â months, with median peanut protein intake of 7.5Â g/wk (interquartile range, 6.0-9.0Â g/wk) in the consumption group compared with 0Â g in the avoidance group. Introduction of peanut in breast-feeding infants did not affect the duration of breast-feeding. There were no differences in anthropometric measurements or energy intakes between groups at any visits. Regular peanut consumption led to differences in dietary intakes. Consumers had higher intakes of fat and avoiders had higher carbohydrate intakes; differences were greatest at the upper quartiles of peanut consumption. Protein intakes remained consistent between groups.ConclusionsIntroduction of peanut proved feasible in infants at high risk of peanut allergy and did not affect the duration of breast-feeding nor impact negatively on growth or nutrition. Energy balance was achieved in both groups through variations in intakes from fat and carbohydrate while protein homeostasis was maintained.
244
Journal: Journal of Allergy and Clinical Immunology - Volume 138, Issue 4, October 2016, Pages 1108-1118