کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5646771 | 1407071 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases
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کلمات کلیدی
HDPGRKMrgprPTXMCTCNK1RGPCRMRGPRX2G protein–coupled receptor kinaseMCDPCGRPMCTEC50VIPSCAPMCC3aRPGD2EPOCTMCHbdMBPMMCDRGG protein–coupled receptor - G گیرنده پروتئینی همراه استMAPK - MAPKhuman β-defensin - β-defensin انسانOrai - آب و هواAsthma - آسمeosinophil peroxidase - ائوزینوفیل پراکسیدازchronic urticaria - داروی مزمن مزمنConnective tissue mast cell - سلول مشتق شده بافت اتصالMucosal mast cell - سلول های مزانشیمی مخاطیPeritoneal mast cell - سلول های مغز پریتونالpertussis toxin - سموم سورافنیSubstance P - ماده PMast cells - ماست سل هاMast cell - ماستسلNeuropeptides - نوروپپتیدهاmajor basic protein - پروتئین اصلی اساسیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenProstaglandin D2 - پروستاگلاندین D2host defense peptide - پپتید دفاع میزبانvasoactive intestinal peptide - پپتید روده روده ایMast cell degranulating peptide - پپتید غشایی سلول مشت سلولیCalcitonin gene–related peptide - پپتید مرتبط با ژن CalcitoninHost defense peptides - پپتیدهای دفاع میزبانSickle cell anemia - کم خونی سلولی شکمdorsal root ganglia - گانگلیس ریشه پشتیNeurokinin 1 receptor - گیرنده neurokinin 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage, contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However, MCs are best known for their roles in allergic and inflammatory diseases, such as anaphylaxis, food allergy, rhinitis, itch, urticaria, atopic dermatitis, and asthma. In addition to the high-affinity IgE receptor (FcεRI), MCs express numerous G protein-coupled receptors (GPCRs), which are the largest group of membrane receptor proteins and the most common targets of drug therapy. Antimicrobial host defense peptides, neuropeptides, major basic protein, eosinophil peroxidase, and many US Food and Drug Administration-approved peptidergic drugs activate human MCs through a novel GPCR known as Mas-related G protein-coupled receptor X2 (MRGPRX2; formerly known as MrgX2). Unique features of MRGPRX2 that distinguish it from other GPCRs include their presence both on the plasma membrane and intracellular sites and their selective expression in MCs. In this article we review the possible roles of MRGPRX2 on host defense, drug-induced anaphylactoid reactions, neurogenic inflammation, pain, itch, and chronic inflammatory diseases, such as urticaria and asthma. We propose that host defense peptides that kill microbes directly and activate MCs through MRGPRX2 could serve as novel GPCR targets to modulate host defense against microbial infection. Furthermore, mAbs or small-molecule inhibitors of MRGPRX2 could be developed for the treatment of MC-dependent allergic and inflammatory disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 138, Issue 3, September 2016, Pages 700-710
Journal: Journal of Allergy and Clinical Immunology - Volume 138, Issue 3, September 2016, Pages 700-710
نویسندگان
Hariharan PhD, Kshitij PhD, Hydar PhD,